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    VHS3 phosphopantothenoylcysteine decarboxylase complex subunit VHS3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VHS3
    Official Full Name
    phosphopantothenoylcysteine decarboxylase complex subunit VHS3
    Primary source
    SGD:S000005580
    Locus tag
    YOR054C
    See related
    AllianceGenome:SGD:S000005580; FungiDB:YOR054C; VEuPathDB:YOR054C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-05
    Summary
    Enables protein phosphatase inhibitor activity. Contributes to phosphopantothenoylcysteine decarboxylase activity. Involved in coenzyme A biosynthetic process and intracellular monoatomic cation homeostasis. Part of CoA-synthesizing protein complex and phosphopantothenoylcysteine decarboxylase complex. Used to study dilated cardiomyopathy. Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VHS3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (427833..429857, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ett1p Neighboring gene Tmc1p Neighboring gene rRNA-binding endoribonuclease Neighboring gene co-chaperone SGT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Ruiz A, et al. Nat Chem Biol, 2009 Dec. PMID 19915539
    2. Functional mapping of the disparate activities of the yeast moonlighting protein Hal3. Abrie JA, et al. Biochem J, 2012 Mar 1. PMID 22124281
    3. Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. Ruiz A, et al. J Biol Chem, 2004 Aug 13. PMID 15192104
    4. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Abrie JA, et al. Sci Rep, 2015 Oct 30. PMID 26514574, Free PMC Article
    5. Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function. Santolaria C, et al. Sci Rep, 2018 Oct 2. PMID 30279472, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to phosphopantothenoylcysteine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to phosphopantothenoylcysteine decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular monoatomic cation homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular monoatomic cation homeostasis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CoA-synthesizing protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphopantothenoylcysteine decarboxylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphopantothenoylcysteine decarboxylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphopantothenoylcysteine decarboxylase complex subunit VHS3
    NP_014697.1
    • Negative regulatory subunit of protein phosphatase 1 Ppz1p; involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      427833..429857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183473.1 → NP_014697.1  TPA: phosphopantothenoylcysteine decarboxylase complex subunit VHS3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014697.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2B8, O00019, Q08438
      UniProtKB/TrEMBL
      B5VRV3, N1NYA2
      Conserved Domains (2) summary
      COG0452
      Location:185 → 575
      CoaBC; Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme transport and metabolism]
      cl19190
      Location:434 → 561
      Flavoprotein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08438.1

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