ASE1 Ase1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ASE1
Official Full Name: Ase1p
Primary source: SGD:S000005584
Locus tag: YOR058C
See related: AllianceGenome:SGD:S000005584; FungiDB:YOR058C; VEuPathDB:YOR058C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YOR29-09
Summary: Enables microtubule binding activity. Involved in microtubule cytoskeleton organization and septum digestion after cytokinesis. Located in mitotic spindle midzone and nuclear microtubule. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ASE1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (433688..436345, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
Title: Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone.
Title: Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone.
When yeast cells were treated with hydroxyurea to block DNA synthesis and induce replication stress, we found that Ase1, a conserved spindle midzone protein, appeared as two short protein isoforms in addition to the full-length protein.
Title: Replicative stress induces intragenic transcription of the ASE1 gene that negatively regulates Ase1 activity.
the requirement of CDK for phosphorylation of the spindle midzone component Ase1p and its significance to spindle assembly
Title: Ase1p phosphorylation by cyclin-dependent kinase promotes correct spindle assembly in S. cerevisiae.
Review identifies Ase1 as a key Cdc14 substrate and elucidates the coordination of spindle midzone assembly with metaphase to anaphase transition.
Title: Assembling the spindle midzone in the right place at the right time.
Ase1p and Cin8p affect nuclear positioning through astral micro-tubule-dependent mechanisms.
Title: The spindle midzone microtubule-associated proteins Ase1p and Cin8p affect the number and orientation of astral microtubules in Saccharomyces cerevisiae.
A pathway regulating IPL1 and the spindle midzone protein Ase1 regulates spindle assembly.
Title: A pathway containing the Ipl1/aurora protein kinase and the spindle midzone protein Ase1 regulates yeast spindle assembly.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in initial mitotic spindle pole body separation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule bundle formation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle elongation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septum digestion after cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	HDA more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ase1p

NP_116582.1

Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

433688..436345 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183477.1 → NP_116582.1 TPA: Ase1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116582.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2C1, P50275

UniProtKB/TrEMBL

A6ZNR0, C8ZI19, G2WMT6, N1P305

Conserved Domains (1) summary

pfam03999
Location:121 → 800

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)