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    CUZ1 Cuz1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CUZ1
    Official Full Name
    Cuz1p
    Primary source
    SGD:S000005099
    Locus tag
    YNL155W
    See related
    AllianceGenome:SGD:S000005099; FungiDB:YNL155W; VEuPathDB:YNL155W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables proteasome binding activity. Involved in cellular response to arsenic-containing substance and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Orthologous to several human genes including ZFAND1 (zinc finger AN1-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CUZ1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (342516..343340)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene phosphatase regulator Neighboring gene Nsg2p Neighboring gene uncharacterized protein Neighboring gene serine/threonine protein kinase YCK2 Neighboring gene tubulin-binding prefolding complex subunit GIM3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins. Sun ZJ, et al. PLoS One, 2016. PMID 27662200, Free PMC Article
    2. Genomic-scale comparison of sequence- and structure-based methods of function prediction: does structure provide additional insight? Fetrow JS, et al. Protein Sci, 2001 May. PMID 11316881, Free PMC Article
    3. Disruption and basic phenotypic analysis of six novel genes from the left arm of chromosome XIV of Saccharomyces cerevisiae. Dueñas E, et al. Yeast, 1999 Jan 15. PMID 10028186
    4. Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity. Hanna J, et al. J Biol Chem, 2014 Jan 17. PMID 24297164, Free PMC Article
    5. Unraveling networks of co-regulated genes on the sole basis of genome sequences. Brohée S, et al. Nucleic Acids Res, 2011 Aug. PMID 21572103, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cuz1/Ynl155w is proposed to protect cells from metalloid-induced proteotoxicity by delivering ubiquitinated substrates to Cdc48 and the proteasome for destruction.
      Title: Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity.
    2. Cuz1 helps limit the accumulation of ubiquitin conjugates on both the proteasome and Cdc48, suggesting a possible role in the transfer of ubiquitylated substrates from Cdc48 to the proteasome
      Title: A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to arsenic-containing substance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cuz1p
    NP_014244.1
    • Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      342516..343340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182993.1 → NP_014244.1  TPA: Cuz1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014244.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W128, P53899
      UniProtKB/TrEMBL
      B3LP10, C7GXV5, C8ZG74, N1NWH3
      Conserved Domains (2) summary
      smart00154
      Location:18 → 55
      ZnF_AN1; AN1-like Zinc finger
      COG3582
      Location:90 → 274
      COG3582; Predicted nucleic acid binding protein containing the AN1-type Zn-finger [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53899.1

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