U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ksr1 kinase suppressor of ras 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 108348076, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Symbol
    Ksr1provided by RGD
    Full Name
    kinase suppressor of ras 1provided by RGD
    Primary source
    RGD:1308105
    See related
    EnsemblRapid:ENSRNOG00000012818 AllianceGenome:RGD:1308105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ksr
    Summary
    Enables mitogen-activated protein kinase kinase binding activity. Predicted to be involved in intracellular signaling cassette; regulation of MAP kinase activity; and regulation of cell population proliferation. Predicted to act upstream of or within MAPK cascade and positive regulation of MAPK cascade. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human KSR1 (kinase suppressor of ras 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ksr1 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (64459786..64596083, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63961771..64098076, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (66346100..66482396, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 2, pseudogene 1 Neighboring gene galectin 5 Neighboring gene galectin 9 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion like 2 Neighboring gene uncharacterized LOC120095152 Neighboring gene WD repeat and SOCS box-containing 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Effect of lentiviral vector-mediated KSR1 gene silencing on the proliferation of renal tubular epithelial cells and expression of inflammatory factors in a rat model of ischemia/reperfusion injury. Bai Y, et al. Acta Biochim Biophys Sin (Shanghai), 2018 Aug 1. PMID 30020400
    2. KSR1 regulates BRCA1 degradation and inhibits breast cancer growth. Stebbing J, et al. Oncogene, 2015 Apr 16. PMID 24909178
    3. Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Lozano J, et al. Cancer Res, 2003 Jul 15. PMID 12874031
    4. Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex. Nemoto S, et al. Am J Physiol Heart Circ Physiol, 2012 Oct 1. PMID 22886408
    5. AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Smith FD, et al. Nat Cell Biol, 2010 Dec. PMID 21102438, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In type 2 diabetic rats, pravastatin normalizes ET-1-induced contraction in aortic smooth muscle via a suppression of PP2A/KSR1/ERK1/ERK2 activities after an enhancement of Src kinase activity.
      Title: Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.
    2. Findings indicate that kinase suppressor of ras 1 (KSR1) gene silencing might inhibit the expression of inflammatory factors in renal tubular epithelial cells (RTECs) and promote their proliferation renal ischemia/reperfusion (I/R) injury.
      Title: Effect of lentiviral vector-mediated KSR1 gene silencing on the proliferation of renal tubular epithelial cells and expression of inflammatory factors in a rat model of ischemia/reperfusion injury.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP-kinase scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    kinase suppressor of Ras 1
    NP_001369417.1
    XP_006246986.1
    XP_006246988.1
    XP_038940940.1
    XP_038940944.1
    XP_063124323.1
    XP_063124324.1
    XP_063124325.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382488.3 → NP_001369417.1  kinase suppressor of Ras 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AAT0
      Related
      ENSRNOP00000090261.2, ENSRNOT00000104397.2
      Conserved Domains (3) summary
      cd14152
      Location:563 → 841
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:41 → 168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cd20872
      Location:334 → 380
      C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      64459786..64596083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246926.5 → XP_006246988.1  kinase suppressor of Ras 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZQW6, D3ZHL1, D3ZVX6
      Related
      ENSRNOP00000049882.4, ENSRNOT00000048407.6
      Conserved Domains (4) summary
      cd00029
      Location:336 → 378
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:577 → 855
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam07714
      Location:578 → 842
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13543
      Location:41 → 168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    2. XM_006246924.5 → XP_006246986.1  kinase suppressor of Ras 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZQW6
      Related
      ENSRNOP00000088976.2, ENSRNOT00000094957.2
      Conserved Domains (4) summary
      cd00029
      Location:336 → 378
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:577 → 855
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam07714
      Location:578 → 842
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13543
      Location:41 → 168
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    3. XM_039085012.2 → XP_038940940.1  kinase suppressor of Ras 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6ADF9
      Related
      ENSRNOP00000096755.2, ENSRNOT00000120025.2
      Conserved Domains (3) summary
      cd14152
      Location:508 → 786
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:61 → 113
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cd20872
      Location:279 → 325
      C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins

    4. XM_063268254.1 → XP_063124324.1  kinase suppressor of Ras 1 isoform X2

      UniProtKB/TrEMBL
      A6HH81

    5. XM_063268253.1 → XP_063124323.1  kinase suppressor of Ras 1 isoform X1

    6. XM_063268255.1 → XP_063124325.1  kinase suppressor of Ras 1 isoform X3

    7. XM_039085016.2 → XP_038940944.1  kinase suppressor of Ras 1 isoform X4

      Conserved Domains (1) summary
      cd14152
      Location:151 → 429
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108284.1: Suppressed sequence

      Description
      NM_001108284.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.