Foxo6 forkhead box O6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxo6provided by RGD
Official Full Name: forkhead box O6provided by RGD
Primary source: RGD:1595858
See related: EnsemblRapid:ENSRNOG00000032639 AllianceGenome:RGD:1595858
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in memory; positive regulation of dendritic spine development; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human FOXO6 (forkhead box O6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 43.9), Muscle (RPKM 35.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (139141329..139161629, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (133856087..133876387, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (139208153..139227288, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet.
Title: FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet.
nerve growth factor could induce the nuclear exclusion of FoxO1-GFP and FoxO3a-GFP in PC12 cells with different properties, but had no effect on FoxO6-GFP's nuclear localization
Title: Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein O6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399214.1 → NP_001386143.1 forkhead box protein O6

Status: INFERRED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

D3ZV21

Related

ENSRNOP00000051244.5, ENSRNOT00000050941.6

Conserved Domains (3) summary

pfam16675
Location:358 → 377

FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2

pfam16676
Location:499 → 537

FOXO-TAD; Transactivation domain of FOXO protein family

cd20063
Location:89 → 176

FH_FOXO6; Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

139141329..139161629 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111222.2 → XP_038967150.1 forkhead box protein O6 isoform X1

UniProtKB/TrEMBL

A0A8I6A2S2

Related

ENSRNOP00000086724.1, ENSRNOT00000095478.2

Conserved Domains (3) summary

pfam16675
Location:381 → 400

FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2

pfam16676
Location:522 → 560

FOXO-TAD; Transactivation domain of FOXO protein family

cl00061
Location:89 → 199

FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins