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    Cep70 centrosomal protein 70 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep70provided by RGD
    Official Full Name
    centrosomal protein 70provided by RGD
    Primary source
    RGD:1561486
    See related
    EnsemblRapid:ENSRNOG00000022845 AllianceGenome:RGD:1561486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in cilium assembly. Predicted to be located in centrosome. Predicted to be active in microtubule organizing center. Orthologous to human CEP70 (centrosomal protein 70). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 124.6), Kidney (RPKM 69.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep70 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (108689562..108742620)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99810270..99863279)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107495326..107548274)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S4, pseudogene 1 Neighboring gene Fas apoptotic inhibitory molecule like Neighboring gene DnaJ heat shock protein family (Hsp40) member C8, pseudogene 3 Neighboring gene extended synaptotagmin 3 Neighboring gene uncharacterized LOC134480219 Neighboring gene muscle RAS oncogene homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    2. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 70 kDa
    Names
    centrosomal protein 70kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428871.1 → NP_001415800.1  centrosomal protein of 70 kDa isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2JU00, A0A0G2K3U9, A6I2D0

    2. NM_001428872.1 → NP_001415801.1  centrosomal protein of 70 kDa isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2JU00, A0A0G2K3U9, A6I2D0

    3. NM_001428873.1 → NP_001415802.1  centrosomal protein of 70 kDa isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5PQQ9
      UniProtKB/TrEMBL
      A0A0G2JU00

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      108689562..108742620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265896.1 → XP_063121966.1  centrosomal protein of 70 kDa isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU00, A0A0G2K3U9, A6I2D0

    2. XM_063265900.1 → XP_063121970.1  centrosomal protein of 70 kDa isoform X4

      UniProtKB/Swiss-Prot
      Q5PQQ9
      UniProtKB/TrEMBL
      A0A0G2JU00
      Related
      ENSRNOP00000072786.2, ENSRNOT00000081029.3

    3. XM_063265891.1 → XP_063121961.1  centrosomal protein of 70 kDa isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU00

    4. XM_063265895.1 → XP_063121965.1  centrosomal protein of 70 kDa isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU00, A0A0G2K3U9, A6I2D0

    5. XM_063265890.1 → XP_063121960.1  centrosomal protein of 70 kDa isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU00

    6. XM_063265899.1 → XP_063121969.1  centrosomal protein of 70 kDa isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU00

    7. XM_006243635.3 → XP_006243697.1  centrosomal protein of 70 kDa isoform X2

      Conserved Domains (1) summary
      COG0419
      Location:85 → 348
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    8. XM_006243639.3 → XP_006243701.1  centrosomal protein of 70 kDa isoform X4

      Related
      ENSRNOP00000053430.2, ENSRNOT00000056590.6
      Conserved Domains (1) summary
      PRK12704
      Location:76 → 199
      PRK12704; phosphodiesterase; Provisional

    9. XM_063265897.1 → XP_063121967.1  centrosomal protein of 70 kDa isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU00, A0A0G2K3U9, A6I2D0

    10. XM_063265901.1 → XP_063121971.1  centrosomal protein of 70 kDa isoform X4

      UniProtKB/Swiss-Prot
      Q5PQQ9
      UniProtKB/TrEMBL
      A0A0G2JU00

    11. XM_063265894.1 → XP_063121964.1  centrosomal protein of 70 kDa isoform X2

      Related
      ENSRNOP00000099784.1, ENSRNOT00000153468.1

    12. XM_063265892.1 → XP_063121962.1  centrosomal protein of 70 kDa isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU00

    13. XM_063265903.1 → XP_063121973.1  centrosomal protein of 70 kDa isoform X7

      UniProtKB/TrEMBL
      A0A0G2JU00
      Related
      ENSRNOP00000109250.1, ENSRNOT00000156249.1

    14. XM_006243640.5 → XP_006243702.1  centrosomal protein of 70 kDa isoform X5

      UniProtKB/TrEMBL
      A0A0G2JU00
      Related
      ENSRNOP00000105102.1, ENSRNOT00000121355.1
      Conserved Domains (1) summary
      COG0419
      Location:42 → 305
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    15. XM_063265902.1 → XP_063121972.1  centrosomal protein of 70 kDa isoform X6

      UniProtKB/TrEMBL
      A0A0G2JU00

    16. XM_008766556.3 → XP_008764778.1  centrosomal protein of 70 kDa isoform X8

    17. XM_063265904.1 → XP_063121974.1  centrosomal protein of 70 kDa isoform X9

    RNA

    1. XR_010054011.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQQ9.1 GenPept UniProtKB/Swiss-Prot:Q5PQQ9

    Gene LinkOut

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