Coasy Coenzyme A synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coasyprovided by RGD
Official Full Name: Coenzyme A synthaseprovided by RGD
Primary source: RGD:1549767
See related: EnsemblRapid:ENSRNOG00000019918 AllianceGenome:RGD:1549767
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Orthologous to human COASY (Coenzyme A synthase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 152.5), Liver (RPKM 149.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86514850..86519130)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86014566..86018849)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88992413..88996677)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

description of the existence of a novel CoA synthase isoform, which is the product of alternative splicing and possesses a 29aa extension at the N-terminus; isoform is termed CoASy beta.
Title: Identification of a novel CoA synthase isoform, which is primarily expressed in the brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables dephospho-CoA kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dephospho-CoA kinase activity	ISO Inferred from Sequence Orthology more info
enables pantetheine-phosphate adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pantetheine-phosphate adenylyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in coenzyme A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within coenzyme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in coenzyme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in purine nucleoside bisphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine ribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ribonucleoside bisphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: bifunctional coenzyme A synthase

Names: CoA synthase

NP_001006955.1

EC 2.7.1.24

EC 2.7.7.3

XP_006247338.1

EC 2.7.1.24

EC 2.7.7.3

XP_038941544.1

EC 2.7.1.24

EC 2.7.7.3

XP_063124807.1

EC 2.7.1.24

EC 2.7.7.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006954.1 → NP_001006955.1 bifunctional coenzyme A synthase precursor

See identical proteins and their annotated locations for NP_001006955.1

Status: PROVISIONAL

Source sequence(s)

BC083781

UniProtKB/TrEMBL

Q5XIA5

Related

ENSRNOP00000027061.2, ENSRNOT00000027061.5

Conserved Domains (2) summary

cd02164
Location:192 → 338

PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes

cd02022
Location:359 → 535

DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86514850..86519130

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247276.5 → XP_006247338.1 bifunctional coenzyme A synthase isoform X1

See identical proteins and their annotated locations for XP_006247338.1

UniProtKB/TrEMBL

Q5XIA5

Conserved Domains (2) summary

cd02164
Location:192 → 338

PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes

cd02022
Location:359 → 535

DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
XM_039085616.2 → XP_038941544.1 bifunctional coenzyme A synthase isoform X2

Conserved Domains (2) summary

cd02022
Location:65 → 241

DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

cl00015
Location:1 → 44

nt_trans; nucleotidyl transferase superfamily
XM_063268737.1 → XP_063124807.1 bifunctional coenzyme A synthase isoform X2