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    Tmem131 Transmembrane protein 131 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem131provided by FlyBase
    Official Full Name
    Transmembrane protein 131provided by FlyBase
    Primary source
    FLYBASE:FBgn0034060
    Locus tag
    Dmel_CG8370
    See related
    AllianceGenome:FB:FBgn0034060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8370; Dmel\CG8370; tmem131
    Summary
    Involved in collagen biosynthetic process. Located in endomembrane system. Is expressed in germline cell. Orthologous to human TMEM131 (transmembrane protein 131). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmem131 in Genome Data Viewer
    Location:
    52D11-52D12; 2-76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16001181..16006901)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11888686..11894406)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Peroxin 11a/b Neighboring gene uncharacterized protein Neighboring gene ATP citrate lyase Neighboring gene Ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta1 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Zhang Z, et al. Sci Adv, 2020 Feb. PMID 32095531, Free PMC Article
    2. Genome-wide identification of alternatively spliced mRNA targets of specific RNA-binding proteins. Robida MD, et al. PLoS One, 2007 Jun 13. PMID 17565373, Free PMC Article
    3. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
    4. Cytoplasmic polyadenylation is a major mRNA regulator during oogenesis and egg activation in Drosophila. Cui J, et al. Dev Biol, 2013 Nov 1. PMID 23978535, Free PMC Article
    5. A genomic analysis of Drosophila somatic sexual differentiation and its regulation. Arbeitman MN, et al. Development, 2004 May. PMID 15056610

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 131
    Names
    CG8370-PA
    CG8370-PB
    Tmem131-PA
    Tmem131-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16001181..16006901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137229.3 → NP_611073.2  transmembrane protein 131, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611073.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LFJ4, Q0IGX2, Q960K9, Q9V7H4
      Related
      FBpp0086345
      Conserved Domains (1) summary
      pfam12371
      Location:54 → 137
      TMEM131_like; Transmembrane protein 131-like

    2. NM_001299542.1 → NP_001286471.1  transmembrane protein 131, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286471.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LFJ4, Q0IGX2, Q960K9, Q9V7H4
      Conserved Domains (1) summary
      pfam12371
      Location:54 → 137
      TMEM131_like; Transmembrane protein 131-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFJ4 A0A0B4LFJ4
    Q9V7H4.2 Q9V7H4

    Gene LinkOut

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