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    Uba3 Ubiquitin-like activating enzyme 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uba3provided by FlyBase
    Official Full Name
    Ubiquitin-like activating enzyme 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0263697
    Locus tag
    Dmel_CG13343
    See related
    AllianceGenome:FB:FBgn0263697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13343; Dmel\CG13343; dUba3; l(2)SH2 2028; l(2)SH2028
    Summary
    Contributes to NEDD8 activating enzyme activity. Involved in negative regulation of smoothened signaling pathway; positive regulation of peptidoglycan recognition protein signaling pathway; and protein neddylation. Part of NAE1-UBA3 complex. Is expressed in wing disc. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Uba3 in Genome Data Viewer
    Location:
    50C6-50C6; 2-68 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13858952..13860432)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9746457..9747937)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44367 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tumbleweed Neighboring gene uncharacterized protein Neighboring gene short stop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of Uba3 (O.2.2) , a pupal lethal mutation in Drosophila melanogaster. Mast E, et al. MicroPubl Biol, 2022. PMID 35622528, Free PMC Article
    2. A Cul-3-BTB ubiquitylation pathway regulates junctional levels and asymmetry of core planar polarity proteins. Strutt H, et al. Development, 2013 Apr. PMID 23487316, Free PMC Article
    3. In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling. Du J, et al. PLoS One, 2011. PMID 21931660, Free PMC Article
    4. UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila. Park ES, et al. Biochem Biophys Res Commun, 2016 Jan 22. PMID 26707646
    5. Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila. Lee D, et al. Nat Commun, 2024 Jan 11. PMID 38212312, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that two novel genes dUba3 (CG13343) and dUbc12 (CG7375) played a critical role in Hh signal transduction.
      Title: In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to NEDD8 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NEDD8 activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NAE1-UBA3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like activating enzyme 3
    Names
    CG13343-PA
    Uba3-PA
    human Uba3 homologue
    lethal (2) SH2028
    ubiquitin activating enzyme 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13858952..13860432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137069.4 → NP_610913.1  Ubiquitin-like activating enzyme 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610913.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QPQ3, Q960K2, Q9V6U8
      Related
      FBpp0086711
      Conserved Domains (3) summary
      cd01488
      Location:50 → 346
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:48 → 220
      ThiF; ThiF family
      pfam08825
      Location:357 → 442
      E2_bind; E2 binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V6U8.1 Q9V6U8

    Gene LinkOut

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