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    Srlp Spliceosome-ribosome linker protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41533, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Srlpprovided by FlyBase
    Official Full Name
    Spliceosome-ribosome linker proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038049
    Locus tag
    Dmel_CG5844
    See related
    AllianceGenome:FB:FBgn0038049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5844; Dmel\CG5844
    Summary
    Involved in cellular response to hypoxia. Located in mitochondrial matrix. Is expressed in adult head; adult heart; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Srlp in Genome Data Viewer
    Location:
    87B10-87B10; 3-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12434098..12435643)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8259820..8261365)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Proteasome alpha2 subunit Neighboring gene Activator of SUMO 1 Neighboring gene Desaturase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Desaturase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila melanogaster. Takahashi A, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11259658, Free PMC Article
    2. Srlp is crucial for the self-renewal and differentiation of germline stem cells via RpL6 signals in Drosophila testes. Yu J, et al. Cell Death Dis, 2019 Apr 1. PMID 30931935, Free PMC Article
    3. Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. Chen CL, et al. Proc Natl Acad Sci U S A, 2015 Sep 29. PMID 26362788, Free PMC Article
    4. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Lee SJ, et al. Mol Biol Cell, 2008 Oct. PMID 18653470, Free PMC Article
    5. Drosophila histone locus bodies form by hierarchical recruitment of components. White AE, et al. J Cell Biol, 2011 May 16. PMID 21576393, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Spliceosome-ribosome linker protein
    Names
    CG5844-PA
    Enoyl-CoA hydratase
    Srlp-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12434098..12435643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141942.3 → NP_650199.1  Spliceosome-ribosome linker protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG69
      Related
      FBpp0082063
      Conserved Domains (1) summary
      cl23717
      Location:49 → 259
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG69 Q9VG69

    Gene LinkOut

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