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    SMC1 Structural maintenance of chromosomes 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMC1provided by FlyBase
    Official Full Name
    Structural maintenance of chromosomes 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0040283
    Locus tag
    Dmel_CG6057
    See related
    AllianceGenome:FB:FBgn0040283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF56231; CG6057; Dmel\CG6057; DmSMC1; dSMC1; smc1; Smc1
    Summary
    Enables chromatin binding activity. Involved in negative regulation of gene expression and nervous system development. Located in euchromatin; nucleus; and polytene chromosome. Part of cohesin complex. Colocalizes with chromosome. Is expressed in germarium; organism; and spermatocyte. Used to study Cornelia de Lange syndrome 2. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Orthologous to human SMC1A (structural maintenance of chromosomes 1A) and SMC1B (structural maintenance of chromosomes 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SMC1 in Genome Data Viewer
    Location:
    95D11-95D11; 3-82 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24058287..24062815)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19884009..19888537)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44097 Neighboring gene Phosphatidylserine decarboxylase Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 68 Neighboring gene eukaryotic translation initiation factor 4E homologous protein Neighboring gene Syntaxin 1A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Review: SMCs in the world of chromosome biology- from prokaryotes to higher eukaryotes. Cobbe N, et al. J Struct Biol, 2000 Apr. PMID 10806064
    2. Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced. Subramanian VV, et al. PLoS Genet, 2008 Nov. PMID 19008956, Free PMC Article
    3. Chromatin-associated cohesin turns over extensively and forms new cohesive linkages in Drosophila oocytes during meiotic prophase. Haseeb MA, et al. Curr Biol, 2024 Jul 8. PMID 38870933,
    4. Couples, pairs, and clusters: mechanisms and implications of centromere associations in meiosis. Obeso D, et al. Chromosoma, 2014 Mar. PMID 24126501, Free PMC Article
    5. Increased levels of superoxide dismutase suppress meiotic segregation errors in aging oocytes. Perkins AT, et al. Chromosoma, 2019 Sep. PMID 31037468, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data indicate that the initial meiotic pairing of homologs is not sufficient to yield synapsis exclusively between homologs and provide a model in which meiotic homolog pairing must be stabilized by centromeric SMC1 to ensure proper synapsis
      Title: Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing.
    2. SOLO and SMC1 are both enriched on centromeres throughout prophase I, co-align along the lateral elements of SCs and reciprocally co-immunoprecipitate from ovarian protein extracts.
      Title: The cohesion protein SOLO associates with SMC1 and is required for synapsis, recombination, homolog bias and cohesion and pairing of centromeres in Drosophila Meiosis.
    3. the localization patterns of SOLO and SMC1 indicate that they function together to maintain sister chromatid cohesion in Drosophila meiosis
      Title: SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster.
    4. Meiotic nondisjunction was increased in aged Drosophila oocytes when the cohesin protein SMC1 is reduced.
      Title: Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced.
    5. Two cohesin subunits (SMC1 and SA) are essential for axon pruning.
      Title: piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cohesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    structural maintenance of chromosomes 1
    Names
    CG6057-PA
    SMC1-PA
    Smc1 cohesin subunit
    cohesin
    cohesin complex subunit SMC1
    cohesin subunit SMC1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24058287..24062815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142954.4 → NP_651211.2  structural maintenance of chromosomes 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651211.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N6I4, Q9VCD8
      Related
      FBpp0083926
      Conserved Domains (4) summary
      cd03275
      Location:27 → 171
      ABC_SMC1_euk; ATP-binding cassette domain of eukaryotic SMC1 proteins
      smart00968
      Location:535 → 653
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:26 → 1216
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15771
      Location:697 → 810
      DUF4700; Domain of unknown function (DUF4700)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N6I4 Q9N6I4
    Q9VCD8 Q9VCD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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