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    CtsL1 Cathepsin L1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CtsL1provided by FlyBase
    Official Full Name
    Cathepsin L1provided by FlyBase
    Primary source
    FLYBASE:FBgn0013770
    Locus tag
    Dmel_CG6692
    See related
    AllianceGenome:FB:FBgn0013770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cath L; CathL; CatL; CATL_DROME; CG6692; CL; cp1; Cp1; CP1; CT20780; Cts1; Cts2; CtsL; CTSL; CysP-1; Dcp-1; DCP-1; Dcp1; DCP1; Dmel\CG6692; fs(2)50Ca
    Summary
    Enables cysteine-type endopeptidase activity. Involved in proteolysis involved in protein catabolic process. Located in fusome; late endosome; and lysosome. Is active in autolysosome. Is expressed in several structures, including adult fruitless aSP4 (male) neuron; adult head; ganglia; glial cell; and gut section. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CtsL1 in Genome Data Viewer
    Location:
    50C18-50C20; 2-68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13960675..13967981)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9848180..9855486)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Argonaute-1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L53 Neighboring gene Regulatory particle non-ATPase 13 Neighboring gene uncharacterized protein Neighboring gene Phenylalanyl-tRNA synthetase, mitochondrial Neighboring gene Sulfotransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A putative digestive cysteine proteinase from Drosophila melanogaster is predominantly expressed in the embryonic and larval midgut. Matsumoto I, et al. Eur J Biochem, 1995 Jan 15. PMID 7851441
    2. Cysteine proteinase 1 (CP1), a cathepsin L-like enzyme expressed in the Drosophila melanogaster haemocyte cell line mbn-2. Tryselius Y, et al. Insect Mol Biol, 1997 May. PMID 9099581
    3. P-element-induced male recombination and gene conversion in Drosophila. Preston CR, et al. Genetics, 1996 Dec. PMID 8978049, Free PMC Article
    4. Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme. Deshapriya RM, et al. Zoolog Sci, 2007 Jan. PMID 17409713
    5. Structure and associated mutational effects of the cysteine proteinase (CP1) gene of Drosophila melanogaster. Gray YH, et al. Insect Mol Biol, 1998 Aug. PMID 9662479

    See all (148) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cp1 and cortex glia have roles in in alcohol-related behaviors in Drosophila
      Title: Alcohol sedation in adult Drosophila is regulated by Cysteine proteinase-1 in cortex glia.
    2. Data show that cysteine proteinase 1 (CP1) is expressed in air sac primordium (ASP) and knockdown of CP1 results in suppression of migratory and invasive behavior observed during ASP development.
      Title: A Cathepsin-L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster.
    3. Data show the models of the tertiary structures of cathepsin L constructed by using homology modeling methods.
      Title: Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome.
    4. Premature activation of the effector caspase, dcp1, resulted in a disappearance of filamentous actin, rather than the formation of actin bundles, suggesting that dcp-1 activity must be restrained in late oogenesis.
      Title: Stage-specific regulation of caspase activity in drosophila oogenesis.
    5. Drosophila decapping protein 1, dDcp1, is a posterior group gene required for the transport of osk mRNA.
      Title: Drosophila decapping protein 1, dDcp1, is a component of the oskar mRNP complex and directs its posterior localization in the oocyte.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in autolysosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cathepsin L1
    Names
    CG6692-PA
    CG6692-PC
    CG6692-PD
    CG6692-PE
    Cathepsin-L
    Cathepsin-L-like protease
    CathepsinL
    CtsL1-PA
    CtsL1-PC
    CtsL1-PD
    CtsL1-PE
    L-like cysteine protease
    cathepsin L
    cysteine proteinase 1
    cysteine proteinase-1
    drosophila cysteine proteinase-1
    NP_001188921.1
    NP_523735.2
    NP_725347.1
    NP_725348.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13960675..13967981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166026.3 → NP_725347.1  cathepsin L1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV44
      Related
      FBpp0086718
      Conserved Domains (2) summary
      smart00848
      Location:29 → 88
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:124 → 340
      Peptidase_C1; Papain family cysteine protease

    2. NM_079011.3 → NP_523735.2  cathepsin L1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523735.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97431, Q5U121, Q95029
      UniProtKB/TrEMBL
      C6SV44
      Related
      FBpp0086719
      Conserved Domains (2) summary
      smart00848
      Location:59 → 118
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:154 → 370
      Peptidase_C1; Papain family cysteine protease

    3. NM_166027.3 → NP_725348.2  cathepsin L1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725348.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV44
      Conserved Domains (2) summary
      smart00848
      Location:32 → 85
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:121 → 337
      Peptidase_C1; Papain family cysteine protease

    4. NM_001201992.1 → NP_001188921.1  cathepsin L1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD48
      Conserved Domains (1) summary
      pfam00112
      Location:32 → 248
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD48 A0A0B4JD48
    Q95029.2 Q95029

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