U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MFS14 Major Facilitator Superfamily Transporter 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46085, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MFS14provided by FlyBase
    Official Full Name
    Major Facilitator Superfamily Transporter 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0010651
    Locus tag
    Dmel_CG15095
    See related
    AllianceGenome:FB:FBgn0010651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    8717; CG15095; Dmel\CG15095; l(2)08717; l208717; lethal (2) 08717; lethal(2)08717
    Summary
    Predicted to enable transmembrane transporter activity. Involved in response to hypoxia and wing disc dorsal/ventral pattern formation. Located in plasma membrane. Is expressed in several structures, including adult CNS glial cell; amnioproctodeal invagination; amnioserosa anlage; anterior endoderm; and embryonic/larval midgut primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MFS14 in Genome Data Viewer
    Location:
    55F3-55F4; 2-86 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18796975..18803727, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14684480..14691232, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Major Facilitator Superfamily Transporter 15 Neighboring gene long non-coding RNA:CR44468 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43418

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mitonuclear Interactions Mediate Transcriptional Responses to Hypoxia in Drosophila. Mossman JA, et al. Mol Biol Evol, 2017 Feb 1. PMID 28110272, Free PMC Article
    2. Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster. Azad P, et al. PLoS One, 2009. PMID 19401761, Free PMC Article
    3. Embryonic expression patterns of Drosophila ACS family genes related to the human sialin gene. Laridon B, et al. Gene Expr Patterns, 2008 Apr. PMID 18255354
    4. A screen for genes expressed in the olfactory organs of Drosophila melanogaster identifies genes involved in olfactory behaviour. Tunstall NE, et al. PLoS One, 2012. PMID 22530061, Free PMC Article
    5. Identification of receptor-tyrosine-kinase-signaling target genes reveals receptor-specific activities and pathway branchpoints during Drosophila development. Leatherbarrow JR, et al. Genetics, 2009 Apr. PMID 19189950, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    major facilitator superfamily transporter 14
    Names
    CG15095-PA
    CG15095-PB
    CG15095-PC
    MFS14-PA
    MFS14-PB
    MFS14-PC
    lethal (2) 08717

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18796975..18803727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299662.1 → NP_001286591.1  major facilitator superfamily transporter 14, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286591.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRP7, Q9V8M9
      Conserved Domains (2) summary
      cd06174
      Location:81 → 466
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:19 → 477
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    2. NM_166309.1 → NP_725829.2  major facilitator superfamily transporter 14, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725829.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRP7, Q9V8M9
      Related
      FBpp0085816, FBtr0086634
      Conserved Domains (2) summary
      cd06174
      Location:81 → 466
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:19 → 477
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    3. NM_143781.3 → NP_652038.2  major facilitator superfamily transporter 14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652038.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRP7, Q9V8M9
      Related
      FBpp0085817
      Conserved Domains (2) summary
      cd06174
      Location:81 → 466
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:19 → 477
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRP7 Q8MRP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous