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    Snx3 Sorting nexin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx3provided by FlyBase
    Official Full Name
    Sorting nexin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0038065
    Locus tag
    Dmel_CG6359
    See related
    AllianceGenome:FB:FBgn0038065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6359; Dmel\CG6359; DmSNX3; Dsnx3; lincRNA.S6645; snx3; SNX3
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in endocytic recycling; protein stabilization; and wing disc development. Located in early endosome. Part of retromer complex. Is expressed in adult head and adult heart. Orthologous to several human genes including SNX12 (sorting nexin 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Snx3 in Genome Data Viewer
    Location:
    87C3-87C3; 3-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12628031..12630495)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8453753..8456217)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44942 Neighboring gene Vacuolar H[+]-ATPase 55kD subunit Neighboring gene CCR4-NOT transcription complex subunit 10 Neighboring gene antisense RNA:CR46018 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Evi/Wntless in exporting Wnt proteins. Wolf L, et al. Development, 2023 Feb 15. PMID 36763105, Free PMC Article
    2. Mistargeting of secretory cargo in retromer-deficient cells. Neuman SD, et al. Dis Model Mech, 2021 Jan 1. PMID 33380435, Free PMC Article
    3. Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. Maruzs T, et al. Traffic, 2015 Oct. PMID 26172538
    4. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress. Zhang P, et al. Sci Rep, 2016 Feb 18. PMID 26887613, Free PMC Article
    5. Snazarus and its human ortholog SNX25 modulate autophagic flux. Lauzier A, et al. J Cell Sci, 2022 Mar 1. PMID 34821359

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DSNX3 acts as a cargo-specific component of retromer, which is required for endocytic recycling of Wls and Wg/Wnt secretion.
      Title: SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in late endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sorting nexin 3
    Names
    CG6359-PA
    CG6359-PB
    Snx3-PA
    Snx3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12628031..12630495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169476.2 → NP_731727.2  sorting nexin 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731727.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG51
      Conserved Domains (1) summary
      cd06894
      Location:32 → 155
      PX_SNX3_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 3 and related proteins

    2. NM_141957.4 → NP_650214.1  sorting nexin 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG51
      Related
      FBpp0082110
      Conserved Domains (1) summary
      cd06894
      Location:32 → 155
      PX_SNX3_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 3 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG51 Q9VG51

    Gene LinkOut

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