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    Arl1 ADP ribosylation factor-like 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39745, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arl1provided by FlyBase
    Official Full Name
    ADP ribosylation factor-like 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0000115
    Locus tag
    Dmel_CG6025
    See related
    AllianceGenome:FB:FBgn0000115
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    72CDd; Arf; arf72A; Arf72A; arf[72A]; arl; arl1; ARL1; ARL1_DROME; BcDNA:GM20805; CG 6025; CG6025; dArl1; dARL1p; Dmel\CG6025; l(3)72Ae; l(3)72CDd; P25160
    Summary
    Enables GTP binding activity and protein domain specific binding activity. Involved in several processes, including endoplasmic reticulum membrane organization; protein localization to Golgi membrane; and regulation of intracellular transport. Located in trans-Golgi network. Is expressed in adult head and adult heart. Orthologous to human ARL1 (ARF like GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arl1 in Genome Data Viewer
    Location:
    72C1-72C1; 3-43 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15983135..15984362)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15976235..15977462)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene brahma Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA polymerase delta subunit 1 Neighboring gene long non-coding RNA:CR45446 Neighboring gene Huntingtin-interacting protein 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport. Kahn RA, et al. J Biol Chem, 1992 Jun 25. PMID 1618801
    2. The arflike gene encodes an essential GTP-binding protein in Drosophila. Tamkun JW, et al. Proc Natl Acad Sci U S A, 1991 Apr 15. PMID 1901655, Free PMC Article
    3. Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes. Clark J, et al. Proc Natl Acad Sci U S A, 1993 Oct 1. PMID 8415637, Free PMC Article
    4. Drosophila arf72A acts as an essential regulator of endoplasmic reticulum quality control and suppresses autosomal-dominant retinopathy. Lee J, et al. Int J Biochem Cell Biol, 2011 Sep. PMID 21693198
    5. centrosomin's beautiful sister (cbs) encodes a GRIP-domain protein that marks Golgi inheritance and functions in the centrosome cycle in Drosophila. Eisman RC, et al. J Cell Sci, 2006 Aug 15. PMID 16882688

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arl1 does not appear to be required for AP-1 recruitment in all tissues, suggesting that it is crucially required to enhance Arf1 activation at the trans-Golgi in particular tissues.
      Title: The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila.
    2. arf72A acts as an essential regulator of endoplasmic reticulum quality control and suppresses autosomal-dominant retinopathy.
      Title: Drosophila arf72A acts as an essential regulator of endoplasmic reticulum quality control and suppresses autosomal-dominant retinopathy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization to Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to Golgi membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of ER to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein exit from endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADP ribosylation factor-like 1
    Names
    Arf-like 1
    Arf72A
    Arl1-PA
    CG6025-PA
    arflike at 72A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15983135..15984362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079374.4 → NP_524098.2  ADP ribosylation factor-like 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524098.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25160, Q9VUW7
      Related
      FBpp0075272
      Conserved Domains (1) summary
      cd04151
      Location:18 → 175
      Arl1; ADP ribosylation factor 1 (Arf1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25160.5 P25160

    Gene LinkOut

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