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    Eh Eclosion hormone [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ehprovided by FlyBase
    Official Full Name
    Eclosion hormoneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000564
    Locus tag
    Dmel_CG5400
    See related
    AllianceGenome:FB:FBgn0000564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5400; DMEHAB; Dmel\CG5400; Drm-EH; eh; EH; EHAB
    Summary
    Predicted to enable eclosion hormone activity. Involved in ecdysis, chitin-based cuticle. Predicted to be located in extracellular space. Is expressed in several structures, including adult central brain; embryonic central brain neurons; embryonic/larval anterior spiracle; embryonic/larval tracheal section; and neurosecretory cell of brain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    90B1-90B1; 3-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17446642..17448858, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13272364..13274580, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Curly Su Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Down syndrome cell adhesion molecule 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation, characterization and expression of the eclosion hormone gene of Drosophila melanogaster. Horodyski FM, et al. Eur J Biochem, 1993 Jul 15. PMID 8344291
    2. The hormonal coordination of behavior and physiology at adult ecdysis in Drosophila melanogaster. Baker JD, et al. J Exp Biol, 1999 Nov. PMID 10518485
    3. Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral program. Baker JD, et al. J Exp Biol, 2002 Sep. PMID 12151362
    4. Neuroendocrine control of larval ecdysis behavior in Drosophila: complex regulation by partially redundant neuropeptides. Clark AC, et al. J Neurosci, 2004 Apr 28. PMID 15115824, Free PMC Article
    5. Anatomical characterization of PDF-tri neurons and peptidergic neurons associated with eclosion behavior in Drosophila. Selcho M, et al. J Comp Neurol, 2018 Jun 1. PMID 29427506

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ecdysis-triggering hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eclosion hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables eclosion hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide hormone activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ecdysis, chitin-based cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eclosion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of eclosion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eclosion hormone
    Names
    CG5400-PA
    CG5400-PB
    Eh-PA
    Eh-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17446642..17448858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275739.1 → NP_001262668.1  eclosion hormone, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07892, Q4V3X3, Q9VEJ8
      UniProtKB/TrEMBL
      A0A0B4KGU5
      Conserved Domains (1) summary
      pfam04736
      Location:36 → 96
      Eclosion; Eclosion hormone

    2. NM_079662.3 → NP_524386.1  eclosion hormone, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524386.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07892, Q4V3X3, Q9VEJ8
      UniProtKB/TrEMBL
      A0A0B4KGU5
      Related
      FBpp0082885
      Conserved Domains (1) summary
      pfam04736
      Location:36 → 96
      Eclosion; Eclosion hormone
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGU5 A0A0B4KGU5
    Q07892.1 Q07892

    Gene LinkOut

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