Acp26Aa Accessory gland protein 26Aa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Acp26Aaprovided by FlyBase
Official Full Name: Accessory gland protein 26Aaprovided by FlyBase
Primary source: FLYBASE:FBgn0002855
Locus tag: Dmel_CG8982
See related: AllianceGenome:FB:FBgn0002855
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Acp; Acp26a; Acp26A; Acp26Aab; CG8982; Dmel\CG8982; msP355a; mst 355a; Mst26A; Mst26Aa; mst355a; ovulin; Ovulin
Summary: Enables identical protein binding activity. Involved in positive regulation of octopamine signaling pathway; positive regulation of ovulation; and sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; adult hemolymph; genital chamber; reproductive system; and semen-secreting cell of the male accessory gland. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 26A1-26A1; 2-18 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5892883..5893896, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5892883..5893896, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that ovulin increases ovulation through octopamine (OA) neuronal signaling and suggest that seminal proteins can alter reproductive physiology by modulating known female pathways regulating reproduction.
Title: Drosophila seminal protein ovulin mediates ovulation through female octopamine neuronal signaling.
Data show that the levels of a fecundity-stimulating Sfp (ovulin) were significantly lower in M females relative to V females, at the same time point shortly after the end of mating.
Title: Protein-specific manipulation of ejaculate composition in response to female mating status in Drosophila melanogaster.
Results reveal a rather flexible sex peptide that lacks a compact folded structure in solution.
Title: NMR studies of the solution conformation of the sex peptide from Drosophila melanogaster.
Because ovulin's self-interaction requires only small conserved domains, the rest of the molecule can be relatively tolerant to mutations.
Title: Immortal coils: conserved dimerization motifs of the Drosophila ovulation prohormone ovulin.
ovulin's cleavage in mated females is not destructive and instead may liberate additional functional products with potential to modulate ovulation independently
Title: Two cleavage products of the Drosophila accessory gland protein ovulin can independently induce ovulation.
Domains involved in ovulin's self-interaction form a conserved structural backbone for the protein, resulting in greater evolutionary flexibility at other sites.
Title: Evidence for structural constraint on ovulin, a rapidly evolving Drosophila melanogaster seminal protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mating	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of octopamine signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sexual reproduction	HEP more info	PubMed
involved_in sexual reproduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in sperm competition	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISM Inferred from Sequence Model more info	PubMed
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	ISM Inferred from Sequence Model more info	PubMed