S Star [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sprovided by FlyBase
Official Full Name: Starprovided by FlyBase
Primary source: FLYBASE:FBgn0003310
Locus tag: Dmel_CG4385
See related: AllianceGenome:FB:FBgn0003310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4385; Dmel\CG4385; E(Raf)2B; EC2-2; EK2-2; ES2-4; EY2-4; fltr; l(2)05671; l(2)07056; l(2)21Eb; l(2)c00080; l(2)k09538; l(2)rK134; s; star; Star/asteroid
Summary: Involved in several processes, including compound eye morphogenesis; nervous system development; and regionalization. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and late endosome membrane. Is expressed in several structures, including anlage in statu nascendi; epithelium; eye photoreceptor cell; head epidermis primordium; and precursor cell of the stomatogastric nervous system. Used to study alcohol use disorder. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 21E4-21E4; 2-1.5 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1049674..1077815, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1049674..1077815, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Export of Spitz-GFP from the endoplasmic reticulum, as well as the trafficking of Spitz-GFP vesicles, depends on both Star and dynein.
Title: Dynein and Star interact in EGFR signaling and ligand trafficking.
Expression in mammalian cell cultures reveals interdependent, but distinct, functions for Star and Rhomboid proteins in the processing of the Drosophila transforming-growth-factor-alpha homologue Spitz.
Title: Expression in mammalian cell cultures reveals interdependent, but distinct, functions for Star and Rhomboid proteins in the processing of the Drosophila transforming-growth-factor-alpha homologue Spitz.
A screen for dominant mutations applied to components in the Drosophila EGF-R pathway
Title: A screen for dominant mutations applied to components in the Drosophila EGF-R pathway.
interacts with Spitz and controls its function in the developing eye
Title: Function of the Drosophila TGF-alpha homolog Spitz is controlled by Star and interacts directly with Star.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0093 (e-PCR)
- UniSTS:61702

Dm2159 (e-PCR)
- UniSTS:81174

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of genital disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor ligand maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor ligand maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor ligand maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian sleep/wake cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stem cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stomatogastric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: star

Names: CG4385-PA; CG4385-PB; S-PA; S-PB; enhancer of GMR-sina 2-4; floater; lethal (2) c00080

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

1049674..1077815 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078726.4 → NP_523450.1 star, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523450.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P42519, Q9VPW0

UniProtKB/TrEMBL

A4UZY2

Related

FBpp0077658

Conserved Domains (1) summary

cl17173
Location:417 → 566

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_164403.2 → NP_722674.1 star, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722674.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P42519, Q9VPW0

UniProtKB/TrEMBL

A4UZY2

Related

FBpp0077659

Conserved Domains (1) summary

cl17173
Location:417 → 566

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...