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    Oct-TyrR Octopamine-Tyramine receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oct-TyrRprovided by FlyBase
    Official Full Name
    Octopamine-Tyramine receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004514
    Locus tag
    Dmel_CG7485
    See related
    AllianceGenome:FB:FBgn0004514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7485; Dmel\CG7485; Dmoct/tyr; DmTAR1; DmTyrR; DrmOTR; hono; l(3)neo30; OA-R; OAR_DROME; Ocr; OcR; Oct/Tyr; OctoR1; OctyR99AB; OTR; tar1; TAR1; Tyr; TyR; TYR; Tyr-dro; Tyr-OctR; TyrR
    Summary
    Enables G protein-coupled amine receptor activity. Involved in octopamine or tyramine signaling pathway; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; and sensory perception of smell. Located in plasma membrane. Is expressed in several structures, including adult gut; adult sensillum; brain; epithelial tube; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oct-TyrR in Genome Data Viewer
    Location:
    79B1-79B2; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22035003..22065279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22028103..22058379)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44687 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster. Nagaya Y, et al. Neurosci Lett, 2002 Sep 6. PMID 12183041
    2. Molecular studies on insect octopamine receptors. Evans PD. EXS, 1993. PMID 8422540
    3. A new method of recording from the giant fiber of Drosophila melanogaster shows that the strength of its auditory inputs remains constant with age. Blagburn JM. PLoS One, 2020. PMID 31910219, Free PMC Article
    4. Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems. Robb S, et al. EMBO J, 1994 Mar 15. PMID 8137817, Free PMC Article
    5. The expression of a cloned Drosophila octopamine/tyramine receptor in Xenopus oocytes. Reale V, et al. Brain Res, 1997 Sep 26. PMID 9374200

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Monoterpenes alter TAR1-driven physiology in Drosophila species.
      Title: Monoterpenes alter TAR1-driven physiology in Drosophila species.
    2. We show that tyramine is released into the CNS to reduce motoneuron intrinsic excitability and responses to excitatory cholinergic input, both by tyramine(honoka) receptor activation and by downstream decrease of L-type calcium current
      Title: Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state.
    3. results uncover a tiny population of male-specific octopamine(oa) receptor neurons that mediate a specific influence of OA on aggression, independent of any effect on arousal.
      Title: A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila.
    4. Site-directed mutagenesis studies show that the receptor binds various amino acids.
      Title: Site-directed mutagenesis studies on the Drosophila octopamine/tyramine receptor.
    5. Correlatoin between cellular changes and insecticidal activity of tested plant essential oils, and suggests that the toxicity of at least two of these chemicals is mediated through the tyramine receptor.
      Title: Molecular response of Drosophila melanogaster tyramine receptor cascade to plant essential oils.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    mobile_element

    • Loc: 22063188-22063510 mobile_element_type = transposon:INE-1{}2169

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled amine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables octopamine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in octopamine or tyramine signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in octopamine or tyramine signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Octopamine-Tyramine receptor
    Names
    CG7485-PA
    CG7485-PB
    Oct-TyrR-PA
    Oct-TyrR-PB
    Oct/Tyr receptor
    Tyramine-receptor
    honoka
    octopamine receptor
    octopamine receptor 1
    octopamine/tyramine receptor
    tyramine receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22035003..22065279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079695.4 → NP_524419.2  Octopamine-Tyramine receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524419.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P22270, Q1RKQ4, Q95YF4, Q9VNW3
      UniProtKB/TrEMBL
      E1JI27
      Related
      FBpp0078132
      Conserved Domains (2) summary
      pfam00001
      Location:126 → 293
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl14876
      Location:113 → 244
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. NM_001170023.2 → NP_001163494.1  Octopamine-Tyramine receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163494.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P22270, Q1RKQ4, Q95YF4, Q9VNW3
      UniProtKB/TrEMBL
      E1JI27
      Conserved Domains (2) summary
      pfam00001
      Location:126 → 293
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl14876
      Location:113 → 244
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JI27 E1JI27
    P22270.2 P22270

    Gene LinkOut

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