rho rhomboid [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rhoprovided by FlyBase
Official Full Name: rhomboidprovided by FlyBase
Primary source: FLYBASE:FBgn0004635
Locus tag: Dmel_CG1004
See related: AllianceGenome:FB:FBgn0004635
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1004; Dmel\CG1004; Dmel\rho; Dmrho; DMRHO; DmRho1; DMRHOa; DMRHOb; DRORHO; iks; Rho; RHO; rho-1; Rho-1; rho1; Rho1; RHOb; rhom; rhomboid/veinlet; ve; Ve
Summary: Enables serine-type endopeptidase activity. Involved in several processes, including neuron differentiation; open tracheal system development; and wing disc development. Located in Golgi membrane; apical part of cell; and late endosome membrane. Is expressed in several structures, including epithelium; eye photoreceptor cell; presumptive wing vein; sense organ; and wing vein. Used to study alcohol use disorder. Orthologous to several human genes including RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 62A2-62A2; 3-0.5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1463811..1468944)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1463811..1468944)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.
Title: Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.
a rhomboid enhancer element that selectively labels four Drosophila embryonic neural precursors, was characterized.
Title: Rhomboid Enhancer Activity Defines a Subset of Drosophila Neural Precursors Required for Proper Feeding, Growth and Viability.
Gro inhibits rho expression in undifferentiated cells and represses the expression of both ato and rho in non-R8 precursors during initiation of photoreceptor differentiation in an E(spl)-dependent manner.
Title: Groucho restricts rhomboid expression and couples EGFR activation with R8 selection during Drosophila photoreceptor differentiation.
Structure and mechanism of rhomboid protease.
Title: Structure and mechanism of rhomboid protease.
analysis of EGFR-dependent network interactions that pattern Drosophila eggshell appendages; each appendage is derived from a primordium comprising a patch of cells expressing broad (br) and an adjacent stripe of cells expressing rhomboid (rho)
Title: EGFR-dependent network interactions that pattern Drosophila eggshell appendages.
rhomboid may function in R8 cells to activate Epidermal growth factor receptor signaling in R7 cells
Title: rhomboid mediates specification of blue- and green-sensitive R8 photoreceptor cells in Drosophila.
Rho-1 and rho-3 exhibit distinct intracellular localization in the eye.
Title: Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases.
Substrate specificity of RHO intramembrane protease is governed by helix-breaking residues in the transmembrane domain.
Title: Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.
Expression in mammalian cell cultures reveals interdependent, but distinct, functions for Star and Rhomboid proteins in the processing of the Drosophila transforming-growth-factor-alpha homologue Spitz.
Title: Expression in mammalian cell cultures reveals interdependent, but distinct, functions for Star and Rhomboid proteins in the processing of the Drosophila transforming-growth-factor-alpha homologue Spitz.
Drosophila RHO is the founder member of a previously undescribed family of serine proteases, and could be directly responsible for the unusual, intramembranous cleavage of EGFr ligands.
Title: A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables serine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of genital disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor ligand maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor ligand maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor ligand maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc proximal/distal pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in maintenance of epithelial integrity, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oenocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oenocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oenocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oenocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal pit formation in open tracheal system	IEP Inferred from Expression Pattern more info	PubMed
involved_in tracheal pit formation in open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed