Awh Arrowhead [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Awhprovided by FlyBase
Official Full Name: Arrowheadprovided by FlyBase
Primary source: FLYBASE:FBgn0013751
Locus tag: Dmel_CG1072
See related: AllianceGenome:FB:FBgn0013751
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: awh; CG1072; Dmel\CG1072; l(3)63Ea; l(3)63Ea/Awh; l(3)64Ea; l(3)SH9; l63Ea
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in compound eye development; imaginal disc development; and regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; anterior-posterior subdivision of organism; head epidermis primordium; and larval imaginal tissue. Orthologous to human LHX6 (LIM homeobox 6) and LHX8 (LIM homeobox 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 63F4-63F4; 3-9 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3846206..3861692)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3846206..3861692)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Arrowhead and Lim1 act redundantly, using Chip as a co-factor, to prevent retinal differentiation in regions of the eye disc destined to become ventral head tissue.
Title: The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: arrowhead

Names: Awh-PA; Awh-PB; Awh-PC; Awh-PD; CG1072-PA; CG1072-PB; CG1072-PC; CG1072-PD; lethal(3)63Ea

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

3846206..3861692

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168042.2 → NP_728906.1 arrowhead, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728906.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18547, Q1LYZ6, Q8IRC7, Q8SZ10, Q9VZM0

Related

FBpp0073014

Conserved Domains (3) summary

cd09373
Location:8 → 61

LIM1_AWH; The first LIM domain of Arrowhead (AWH)

cd09379
Location:69 → 123

LIM2_AWH; The second LIM domain of Arrowhead (AWH)

pfam00046
Location:152 → 205

Homeobox; Homeobox domain
NM_001274450.1 → NP_001261379.1 arrowhead, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261379.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEI5

Conserved Domains (3) summary

cd09373
Location:8 → 61

LIM1_AWH; The first LIM domain of Arrowhead (AWH)

cd09379
Location:69 → 123

LIM2_AWH; The second LIM domain of Arrowhead (AWH)

pfam00046
Location:152 → 204

Homeobox; Homeobox domain
NM_079183.3 → NP_523907.2 arrowhead, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523907.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRC7

Related

FBpp0073013

Conserved Domains (3) summary

cd09373
Location:8 → 61

LIM1_AWH; The first LIM domain of Arrowhead (AWH)

pfam00046
Location:152 → 205

Homeobox; Homeobox domain

cl02475
Location:69 → 123

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001274451.1 → NP_001261380.1 arrowhead, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261380.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PE75

Conserved Domains (3) summary

cd09373
Location:8 → 61

LIM1_AWH; The first LIM domain of Arrowhead (AWH)

cd09379
Location:69 → 123

LIM2_AWH; The second LIM domain of Arrowhead (AWH)

pfam00046
Location:152 → 205

Homeobox; Homeobox domain