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    Pp4-19C Protein phosphatase 19C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pp4-19Cprovided by FlyBase
    Official Full Name
    Protein phosphatase 19Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023177
    Locus tag
    Dmel_CG32505
    See related
    AllianceGenome:FB:FBgn0023177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1459; CG1596; CG18339; CG32505; Dmel\CG32505; DmPpp4-19C; dPP4; PP1; pp4; PP4; PP4 19C; PP4-1; Pp4-19c; PP4-19c; PP4-19C; PP4c; PP4C; Ppp4c; PPP4c; PpX; PPX
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in several processes, including mitotic cell cycle; negative regulation of signal transduction; and regulation of mitotic cell cycle. Located in several cellular components, including centrosome; chromosome, centromeric region; and nucleus. Part of protein phosphatase 4 complex. Is expressed in embryonic brain; embryonic/larval midgut; larval nervous system; larval ventral nerve cord; and organism. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pp4-19C in Genome Data Viewer
    Location:
    19D1-19D1; 1-64 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20421087..20424002, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20292114..20295029, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 19c Neighboring gene Odorant-binding protein 19d Neighboring gene cactin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Silverstein AM, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11904383, Free PMC Article
    2. Phosphorylation and dephosphorylation events allow for rapid segregation of fate determinants during Drosophila neuroblast asymmetric divisions. Sousa-Nunes R, et al. Commun Integr Biol, 2010 Jan. PMID 20539782, Free PMC Article
    3. Amorphous no longer: the centrosome comes into focus. Zimmerman W, et al. Curr Opin Cell Biol, 1999 Feb. PMID 10047524
    4. Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster. Wang N, et al. PLoS One, 2012. PMID 22701670, Free PMC Article
    5. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. Martin-Granados C, et al. Int J Biochem Cell Biol, 2008. PMID 18487071

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein Phosphatase 4 Negatively Regulates the Immune Deficiency-NF-kappaB Pathway during the Drosophila Immune Response.
      Title: Protein Phosphatase 4 Negatively Regulates the Immune Deficiency-NF-κB Pathway during the Drosophila Immune Response.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase 4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 19C
    Names
    CG32505-PA
    CG32505-PE
    CG32505-PG
    CG32505-PH
    CG32505-PI
    Pp4-19C-PA
    Pp4-19C-PE
    Pp4-19C-PG
    Pp4-19C-PH
    Pp4-19C-PI
    phosphoprotein phosphatase 4
    protein phosphatase 1
    protein phosphatase 4
    protein phosphatase X
    NP_001285489.1
    NP_001285490.1
    NP_001303570.1
    NP_524803.1
    NP_728342.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20421087..20424002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298560.1 → NP_001285489.1  protein phosphatase 19C, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285489.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76932, Q9VR98
      UniProtKB/TrEMBL
      X2JG90
      Conserved Domains (1) summary
      cd07415
      Location:6 → 290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    2. NM_080064.3 → NP_524803.1  protein phosphatase 19C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76932, Q9VR98
      UniProtKB/TrEMBL
      X2JG90
      Related
      FBpp0077016
      Conserved Domains (1) summary
      cd07415
      Location:6 → 290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    3. NM_001316641.1 → NP_001303570.1  protein phosphatase 19C, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76932, Q9VR98
      UniProtKB/TrEMBL
      X2JG90
      Conserved Domains (1) summary
      cd07415
      Location:6 → 290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    4. NM_167703.4 → NP_728342.1  protein phosphatase 19C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76932, Q9VR98
      UniProtKB/TrEMBL
      X2JG90
      Related
      FBpp0077017
      Conserved Domains (1) summary
      cd07415
      Location:6 → 290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    5. NM_001298561.1 → NP_001285490.1  protein phosphatase 19C, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76932, Q9VR98
      UniProtKB/TrEMBL
      X2JG90
      Conserved Domains (1) summary
      cd07415
      Location:6 → 290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76932.1 O76932
    X2JG90 X2JG90

    Gene LinkOut

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