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    Agpat2 1-Acylglycerol-3-phosphate O-acyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34176, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agpat2provided by FlyBase
    Official Full Name
    1-Acylglycerol-3-phosphate O-acyltransferase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0026718
    Locus tag
    Dmel_CG17608
    See related
    AllianceGenome:FB:FBgn0026718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AGPAT; AGPAT1; AGPAT2; CG17608; dAGPAT2; DmAGPAT1/2; Dmel\CG17608; fu12
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in behavioral response to ethanol. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head; amnioserosa; embryonic/larval midgut; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Agpat2 in Genome Data Viewer
    Location:
    29C5-29D1; 2-33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8449691..8463994, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8449691..8463994, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Aminoadipate-semialdehyde dehydrogenase Neighboring gene piragua Neighboring gene dachs Neighboring gene Chemosensory protein A 29a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication. Castorena KM, et al. BMC Genomics, 2010 Mar 17. PMID 20236518, Free PMC Article
    2. Late-life shift in caloric intake affects fly metabolism and longevity. Li M, et al. Proc Natl Acad Sci U S A, 2023 Dec 12. PMID 38064506, Free PMC Article
    3. SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Pagac M, et al. Cell Rep, 2016 Nov 1. PMID 27806294, Free PMC Article
    4. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. Tian Y, et al. PLoS Genet, 2011 Apr. PMID 21533227, Free PMC Article
    5. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-Acylglycerol-3-phosphate O-acyltransferase 2
    Names
    Agpat2-PA
    Agpat2-PB
    Agpat2-PC
    Agpat2-PD
    CG17608-PA
    CG17608-PB
    CG17608-PC
    CG17608-PD
    fu12
    NP_001162912.1
    NP_001285755.1
    NP_609231.2
    NP_723398.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8449691..8463994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135387.4 → NP_609231.2  1-Acylglycerol-3-phosphate O-acyltransferase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609231.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTI0, Q8T9K7
      Related
      FBpp0079310
      Conserved Domains (1) summary
      cd07989
      Location:65 → 248
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    2. NM_001169441.2 → NP_001162912.1  1-Acylglycerol-3-phosphate O-acyltransferase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162912.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTI0, Q8T9K7
      Conserved Domains (1) summary
      cd07989
      Location:65 → 248
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    3. NM_001298826.1 → NP_001285755.1  1-Acylglycerol-3-phosphate O-acyltransferase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTI0, Q8T9K7
      Conserved Domains (1) summary
      cd07989
      Location:65 → 248
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    4. NM_164823.3 → NP_723398.1  1-Acylglycerol-3-phosphate O-acyltransferase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTI0, Q8T9K7
      Conserved Domains (1) summary
      cd07989
      Location:65 → 248
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTI0 Q7KTI0
    Q8T9K7 Q8T9K7

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