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    Ku80 Ku80 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ku80provided by FlyBase
    Official Full Name
    Ku80provided by FlyBase
    Primary source
    FLYBASE:FBgn0041627
    Locus tag
    Dmel_CG18801
    See related
    AllianceGenome:FB:FBgn0041627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS09217.6; CG18801; Dmel\CG18801; DmKu80; Ku; ku80; KU80
    Summary
    Predicted to enable ATP hydrolysis activity; ATP-dependent activity, acting on DNA; and telomeric DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Involved in DNA metabolic process; cellular response to gamma radiation; and response to ethanol. Predicted to be located in nucleus. Predicted to be part of Ku70:Ku80 complex. Used to study alcohol dependence. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple myeloma; and rectum cancer. Orthologous to human XRCC5 (X-ray repair cross complementing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ku80 in Genome Data Viewer
    Location:
    35D4-35D4; 2-51 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15768630..15771159, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15768630..15771159, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Gliotactin Neighboring gene uncharacterized protein Neighboring gene weckle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. Juraeva D, et al. Neuropsychopharmacology, 2015 Jan. PMID 25035082, Free PMC Article
    2. Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks. Min B, et al. Proc Natl Acad Sci U S A, 2004 Jun 15. PMID 15184650, Free PMC Article
    3. A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling. Harpprecht L, et al. Nucleic Acids Res, 2019 Aug 22. PMID 31147711, Free PMC Article
    4. The Ku protein complex is involved in length regulation of Drosophila telomeres. Melnikova L, et al. Genetics, 2005 May. PMID 15781709, Free PMC Article
    5. Continuous tracking of startled Drosophila as an alternative to the negative geotaxis climbing assay. Taylor MJ, et al. J Neurogenet, 2019 Sep. PMID 31290369

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. partial loss of function of Ku80 in these neurons through CRISPR/Cas9-mediated ablation or small RNAs-mediated knockdown suppressed the apoptotic pathway. Thus, partial inhibition of the overactivated Ku80-dependent DNA repair pathway is a promising therapeutic approach in C9ORF72-ALS/FTD.
      Title: Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD.
    2. Genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans generated independent evidence for the involvement of XRCC5 (Ku80) in alcohol dependence
      Title: XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans.
    3. specific regulation of ku80 expression by UTX
      Title: Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.
    4. Role for Ku subunits in the regulation of sperm individualization.
      Title: Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells.
    5. Decrease in gene dosage causes a sharp increase in the frequency of HeT-A and TART attachments to a broken chromosome end and in terminal DNA elongation by gene conversion.
      Title: The Ku protein complex is involved in length regulation of Drosophila telomeres.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ku70:Ku80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ku70:Ku80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ku80
    Names
    CG18801-PA
    Ku80-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15768630..15771159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135923.3 → NP_609767.2  Ku80 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609767.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0CR51, Q9I7M8
      Related
      FBpp0080322
      Conserved Domains (3) summary
      cd00873
      Location:221 → 524
      KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      pfam03731
      Location:7 → 213
      Ku_N; Ku70/Ku80 N-terminal alpha/beta domain
      pfam08785
      Location:562 → 663
      Ku_PK_bind; Ku C terminal domain like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSM8 Q8MSM8
    Q9I7M8 Q9I7M8
    Q9NGX6 Q9NGX6

    Gene LinkOut

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