nAChRalpha5 nicotinic Acetylcholine Receptor alpha5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nAChRalpha5provided by FlyBase
Official Full Name: nicotinic Acetylcholine Receptor alpha5provided by FlyBase
Primary source: FLYBASE:FBgn0028875
Locus tag: Dmel_CG32975
See related: AllianceGenome:FB:FBgn0028875
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AChRalpha5; anon-WO02059370.44; BG:DS05899.4; BG:DS05899.5; CG16878; CG32975; CG4498; CT14633; da5; daf; Dalpha5; Dmel\CG32975; lincRNA.128; lincRNA.S1055; nAChR; nAChRalpha-34E; nAcRalpha-34e; nAcRalpha-34E; Nic 34E
Summary: Enables acetylcholine binding activity. Contributes to acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport. Located in membrane. Part of acetylcholine-gated channel complex. Is expressed in DN1p neurons; adult head; and lamina monopolar neuron L4. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 34F2-34F4; 2-50 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (14040170..14094401)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (14040170..14094401)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dalpha5 and Secreted Scaffold Protein Hig.
Title: Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dα5 and Secreted Scaffold Protein Hig.
D alpha 5 is a component of an alpha-bungarotoxin binding nicotinic acetylcholine receptor from the central nervous system of Drosophila
Title: The Drosophila acetylcholine receptor subunit D alpha5 is part of an alpha-bungarotoxin binding acetylcholine receptor.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acetylcholine binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to acetylcholine-gated monoatomic cation-selective channel activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of acetylcholine-gated channel complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nicotinic acetylcholine receptor alpha5

Names: CG32975-PB; CG32975-PD; CG32975-PH; CG32975-PI; Dalpha5; nAChRalpha5-PB; nAChRalpha5-PD; nAChRalpha5-PH; nAChRalpha5-PI; nicotinic acetylcholine Receptor_34E; nicotinic acetylcholine receptor alpha 34E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

14040170..14094401

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_205985.3 → NP_995707.2 nicotinic acetylcholine receptor alpha5, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995707.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KT97, Q7KT98, Q8T7V5

Conserved Domains (3) summary

TIGR00860
Location:313 → 802

LIC; Cation transporter family protein

pfam02931
Location:313 → 520

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:527 → 797

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001370005.1 → NP_001356885.1 nicotinic acetylcholine receptor alpha5, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A499GGQ3, Q8T7V5

Conserved Domains (1) summary

TIGR00860
Location:313 → 802

LIC; Cation transporter family protein
NM_001259098.3 → NP_001246027.1 nicotinic acetylcholine receptor alpha5, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246027.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KT97, Q7KT98, Q8T7V5

Conserved Domains (3) summary

TIGR00860
Location:313 → 802

LIC; Cation transporter family protein

pfam02931
Location:313 → 520

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:527 → 797

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_205986.4 → NP_995708.1 nicotinic acetylcholine receptor alpha5, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995708.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KT97, Q7KT98, Q8T7V5

Conserved Domains (3) summary

TIGR00860
Location:313 → 802

LIC; Cation transporter family protein

pfam02931
Location:313 → 520

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:527 → 797

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region