eIF4E7 eukaryotic translation initiation factor 4E7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF4E7provided by FlyBase
Official Full Name: eukaryotic translation initiation factor 4E7provided by FlyBase
Primary source: FLYBASE:FBgn0040368
Locus tag: Dmel_CG32859
See related: AllianceGenome:FB:FBgn0040368
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11392; CG11393; CG32859; CT31794; Dmel\CG32859; EG:BACR42I17.1; eIF4E; eIF4E-7; eIF4F
Summary: Enables RNA 7-methylguanosine cap binding activity; eukaryotic initiation factor 4G binding activity; and translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 4F complex. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1158599..1162389, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1052632..1056422, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

crucial role for the Cup-eIF4E complex in ovary-specific developmental programs.
Title: Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA cap binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables eukaryotic initiation factor 4G binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	IPI Inferred from Physical Interaction more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain