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    Rrp45 Rrp45 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32665, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rrp45provided by FlyBase
    Official Full Name
    Rrp45provided by FlyBase
    Primary source
    FLYBASE:FBgn0030789
    Locus tag
    Dmel_CG9606
    See related
    AllianceGenome:FB:FBgn0030789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9606; Dmel\CG9606; dRrp45; rrp45
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Part of exosome (RNase complex). Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; head mesoderm; and salivary gland body primordium. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1D. Orthologous to human EXOSC9 (exosome component 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Rrp45 in Genome Data Viewer
    Location:
    15A8-15A8; 1-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16789405..16791266, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16683438..16685299, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L22 Neighboring gene uncharacterized protein Neighboring gene SIN3-associated polypeptide 30 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rat1 Interacting Protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits. Kiss DL, et al. RNA, 2010 Apr. PMID 20185544, Free PMC Article
    2. Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions. Mamolen M, et al. Nucleic Acids Res, 2010 Sep. PMID 20421210, Free PMC Article
    3. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Forler D, et al. Nat Biotechnol, 2003 Jan. PMID 12483225
    4. Interdependent nucleocytoplasmic trafficking and interactions of Dis3 with Rrp6, the core exosome and importin-alpha3. Graham AC, et al. Traffic, 2009 May. PMID 19220816, Free PMC Article
    5. The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. Andrulis ED, et al. Nature, 2002 Dec 19-26. PMID 12490954

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U1 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U5 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rrp45
    Names
    CG9606-PA
    CG9606-PB
    Rrp45-PA
    Rrp45-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16789405..16791266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298424.1 → NP_001285353.1  Rrp45, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4A9, Q9VXB2
      Conserved Domains (2) summary
      cd11368
      Location:13 → 268
      RNase_PH_RRP45; RRP45 subunit of eukaryotic exosome
      COG2123
      Location:16 → 276
      Rrp42; Exosome complex RNA-binding protein Rrp42, RNase PH superfamily [Translation, ribosomal structure and biogenesis]

    2. NM_132935.3 → NP_573163.1  Rrp45, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4A9, Q9VXB2
      Related
      FBpp0074129
      Conserved Domains (2) summary
      cd11368
      Location:13 → 268
      RNase_PH_RRP45; RRP45 subunit of eukaryotic exosome
      COG2123
      Location:16 → 276
      Rrp42; Exosome complex RNA-binding protein Rrp42, RNase PH superfamily [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T4A9 Q8T4A9

    Gene LinkOut

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