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    CG6179 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6179provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030915
    Locus tag
    Dmel_CG6179
    See related
    AllianceGenome:FB:FBgn0030915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6179; NOSIPL
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in negative regulation of nitric-oxide synthase activity. Part of catalytic step 2 spliceosome. Orthologous to human NOSIP (nitric oxide synthase interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6179 in Genome Data Viewer
    Location:
    17A9-17A9; 1-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18380082..18381479)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18274115..18275512)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cyclic-AMP response element binding protein B Neighboring gene long non-coding RNA:CR43686 Neighboring gene porcupine Neighboring gene Coat Protein (coatomer) beta Neighboring gene Transferrin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Poly(A) signals located near the 5' end of genes are silenced by a general mechanism that prevents premature 3'-end processing. Guo J, et al. Mol Cell Biol, 2011 Feb. PMID 21135120, Free PMC Article
    2. The Drosophila actin nucleator DAAM is essential for left-right asymmetry. Chougule A, et al. PLoS Genet, 2020 Apr. PMID 32324733, Free PMC Article
    3. Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity. Upadhyay A, et al. Mol Neurodegener, 2023 Sep 14. PMID 37710351, Free PMC Article
    4. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article
    5. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of nitric-oxide synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6179-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18380082..18381479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133060.3 → NP_573288.1  uncharacterized protein Dmel_CG6179 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWV8
      UniProtKB/TrEMBL
      A8E752
      Related
      FBpp0074330
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cl17238
      Location:200 → 282
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWV8.1 Q9VWV8

    Gene LinkOut

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