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    AANATL2 Arylalkylamine N-acetyltransferase-like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AANATL2provided by FlyBase
    Official Full Name
    Arylalkylamine N-acetyltransferase-like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031791
    Locus tag
    Dmel_CG9486
    See related
    AllianceGenome:FB:FBgn0031791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aaNAT2; AANAT2; CG9486; DmAANATL2; Dmel\CG9486
    Summary
    Enables acyl-CoA N-acyltransferase activity and aralkylamine N-acetyltransferase activity. Is expressed in adult abdomen and adult thorax. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AANATL2 in Genome Data Viewer
    Location:
    26C1-26C1; 2-19 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6255859..6256822)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6255859..6256822)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44823 Neighboring gene UDP-glycosyltransferase family 37 member B1 Neighboring gene Discoidin domain receptor Neighboring gene long non-coding RNA:CR46410 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockdown of arylalkylamine N-acetyltransferase-like 2 in Drosophila melanogaster. Anderson RL, et al. Arch Insect Biochem Physiol, 2019 Dec. PMID 31385627, Free PMC Article
    2. Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2. Dempsey DR, et al. Insect Biochem Mol Biol, 2015 Nov. PMID 26476413, Free PMC Article
    3. Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins. Dempsey DR, et al. FEBS Lett, 2014 Feb 14. PMID 24444601, Free PMC Article
    4. Insect Arylalkylamine N-Acyltransferases: Mechanism and Role in Fatty Acid Amide Biosynthesis. O'Flynn BG, et al. Front Mol Biosci, 2018. PMID 30094237, Free PMC Article
    5. Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster. Amherd R, et al. DNA Cell Biol, 2000 Nov. PMID 11098219

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AANATL2 catalyzes the formation of N-acylarylalkylamides using either different catalytic residues or a different chemical mechanism relative to other D. melanogaster AANATL enzymes.
      Title: Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2.
    2. AANATL2 has a role in the biosynthetic formation of long-chain N-acylserotonins
      Title: Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl-CoA N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aralkylamine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arylalkylamine N-acetyltransferase-like 2
    Names
    AANATL2-PA
    AANATL2-PB
    CG9486-PA
    CG9486-PB
    arylalkylamine N-acetyltransferase 2
    arylalkylamine N-acyltransferase-like 2
    NP_001285667.1
    NP_609005.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6255859..6256822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298738.1 → NP_001285667.1  arylalkylamine N-acetyltransferase-like 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285667.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V4G0, Q9VMG0
      Conserved Domains (1) summary
      pfam00583
      Location:81 → 178
      Acetyltransf_1; Acetyltransferase (GNAT) family

    2. NM_135161.3 → NP_609005.1  arylalkylamine N-acetyltransferase-like 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609005.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V4G0, Q9VMG0
      Related
      FBpp0078873
      Conserved Domains (1) summary
      pfam00583
      Location:81 → 178
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMG0.1 Q9VMG0

    Gene LinkOut

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