PDZ-GEF PDZ domain-containing guanine nucleotide exchange factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PDZ-GEFprovided by FlyBase
Official Full Name: PDZ domain-containing guanine nucleotide exchange factorprovided by FlyBase
Primary source: FLYBASE:FBgn0265778
Locus tag: Dmel_CG9491
See related: AllianceGenome:FB:FBgn0265778
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9491; D-PDZGEF; DGEF; dizzy; Dmel\CG9491; dPDZ-GEF; dzy; Dzy; EC2-8; GEF; gef26; Gef26; l(2)k13720; PDF-GEF Dizzy
Summary: Enables small GTPase binding activity. Involved in several processes, including hemocyte migration; positive regulation of ERK1 and ERK2 cascade; and regulation of photoreceptor cell differentiation. Located in apicolateral plasma membrane. Colocalizes with adherens junction. Is expressed in adult head; ectoderm; ovary; and spermathecal duct. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to several human genes including RAPGEF2 (Rap guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 26C2-26C3; 2-19 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6323767..6332789)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6323767..6332789)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gef26-Rap1 signaling pathway regulates both synaptic growth and neuronal survival by controlling BMP signaling.
Title: The Rap activator Gef26 regulates synaptic growth and neuronal survival via inhibition of BMP signaling.
Data suggest that dPDZ-GEF/Rap1/Canoe signaling modulates cell shape and apicolateral cell constriction in embryonic and wing disc epithelia.
Title: The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis.
PDZ-GEF is an upstream regulator of morphogenetic pathways and is involved in Drosophila photoreceptor development
Title: Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.
Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.
Title: Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.
The PDZ-GEF Dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in the Drosophila embryo.
Title: The PDZ-GEF dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in the Drosophila embryo.
Rap-GEF/Rap signaling restricts the formation of supernumerary spermathecae in Drosophila melanogaster.
Title: Rap-GEF/Rap signaling restricts the formation of supernumerary spermathecae in Drosophila melanogaster.
Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis.
Title: Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R7 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in adherens junction assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in substrate-dependent cell migration, cell extension	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PDZ domain-containing guanine nucleotide exchange factor

Names: CG9491-PA; CG9491-PB; CG9491-PC; CG9491-PD; GEF; Gef26; PDZ-GEF-PA; PDZ-GEF-PB; PDZ-GEF-PC; PDZ-GEF-PD; PDZ-GEF/Dizzy; dizzy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6323767..6332789

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273197.1 → NP_001260126.1 PDZ domain-containing guanine nucleotide exchange factor, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260126.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z025, B8Q6A6

Conserved Domains (7) summary

cd01785
Location:757 → 841

PDZ_GEF_RA; Ubiquitin-like domain of PDZ_GEF_RA

smart00229
Location:279 → 400

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

COG0265
Location:422 → 494

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00038
Location:128 → 237

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00992
Location:404 → 494

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00617
Location:871 → 1050

RasGEF; RasGEF domain

pfam12595
Location:1252 → 1357

Rhomboid_SP; Rhomboid serine protease
NM_135168.5 → NP_609012.2 PDZ domain-containing guanine nucleotide exchange factor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609012.2

Status: REVIEWED

UniProtKB/TrEMBL

Q95V18, Q9VMF3

Related

FBpp0078879

Conserved Domains (7) summary

cd01785
Location:757 → 841

PDZ_GEF_RA; Ubiquitin-like domain of PDZ_GEF_RA

smart00229
Location:279 → 400

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

COG0265
Location:422 → 494

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00038
Location:128 → 237

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00992
Location:404 → 494

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00617
Location:871 → 1050

RasGEF; RasGEF domain

pfam12595
Location:1252 → 1357

Rhomboid_SP; Rhomboid serine protease
NM_001144325.2 → NP_001137797.1 PDZ domain-containing guanine nucleotide exchange factor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137797.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z025, B8Q6A6

Conserved Domains (7) summary

cd01785
Location:757 → 841

PDZ_GEF_RA; Ubiquitin-like domain of PDZ_GEF_RA

smart00229
Location:279 → 400

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

COG0265
Location:422 → 494

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00038
Location:128 → 237

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00992
Location:404 → 494

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00617
Location:871 → 1050

RasGEF; RasGEF domain

pfam12595
Location:1252 → 1357

Rhomboid_SP; Rhomboid serine protease
NM_001144326.2 → NP_001137798.1 PDZ domain-containing guanine nucleotide exchange factor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137798.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z026, B8Q6A8

Conserved Domains (7) summary

cd01785
Location:757 → 841

PDZ_GEF_RA; Ubiquitin-like domain of PDZ_GEF_RA

smart00229
Location:279 → 400

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

COG0265
Location:422 → 494

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00038
Location:128 → 237

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00992
Location:404 → 494

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00617
Location:871 → 1050

RasGEF; RasGEF domain

pfam12595
Location:1252 → 1357

Rhomboid_SP; Rhomboid serine protease