U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG8353 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34123, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG8353provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032002
    Locus tag
    Dmel_CG8353
    See related
    AllianceGenome:FB:FBgn0032002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8353
    Summary
    Predicted to enable cytidine deaminase activity and zinc ion binding activity. Predicted to be involved in cytidine deamination. Predicted to be active in cytosol. Is expressed in several structures, including anterior endoderm; embryonic primordium of adult muscle precursor; embryonic/larval midgut primordium; gland; and larval muscle system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG8353 in Genome Data Viewer
    Location:
    28F3-28F3; 2-30 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8214045..8215239)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8214045..8215239)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Single stranded-binding protein c31A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Hum Mol Genet, 2019 Mar 15. PMID 30476102, Free PMC Article
    2. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047
    3. Isolation of a natural DNA virus of Drosophila melanogaster, and characterisation of host resistance and immune responses. Palmer WH, et al. PLoS Pathog, 2018 Jun. PMID 29864164, Free PMC Article
    4. Investigating the Evolution of Drosophila STING-Dependent Antiviral Innate Immunity by Multispecies Comparison of 2'3'-cGAMP Responses. Hédelin L, et al. Mol Biol Evol, 2024 Mar 1. PMID 38377349, Free PMC Article
    5. Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. Curtis C, et al. Genome Biol, 2007. PMID 18067683, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytidine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytidine deamination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG8353-PA
    CG8353-PB
    NP_001260233.1
    NP_609196.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8214045..8215239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273304.1 → NP_001260233.1  uncharacterized protein Dmel_CG8353, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260233.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLR2
      Conserved Domains (2) summary
      TIGR01354
      Location:28 → 165
      cyt_deam_tetra; cytidine deaminase, homotetrameric
      cl00269
      Location:29 → 167
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    2. NM_135352.3 → NP_609196.1  uncharacterized protein Dmel_CG8353, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLR2
      Related
      FBpp0079214
      Conserved Domains (2) summary
      TIGR01354
      Location:28 → 165
      cyt_deam_tetra; cytidine deaminase, homotetrameric
      cl00269
      Location:29 → 167
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLR2 Q9VLR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools