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    Scgalpha Sarcoglycan alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scgalphaprovided by FlyBase
    Official Full Name
    Sarcoglycan alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032013
    Locus tag
    Dmel_CG7851
    See related
    AllianceGenome:FB:FBgn0032013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7851; Dmel\CG7851; DmSCG-alphaepsilon; Scg alpha; Scga
    Summary
    Predicted to be a structural constituent of muscle. Predicted to be located in membrane. Predicted to be part of sarcoglycan complex. Is expressed in several structures, including dorsal sensory complex proper primordium; embryonic epidermis; ganglia; gut section; and larval muscle cell. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2D; muscular dystrophy; and myoclonic dystonia 11. Orthologous to human SGCA (sarcoglycan alpha) and SGCE (sarcoglycan epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Scgalpha in Genome Data Viewer
    Location:
    29A3-29A3; 2-31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8303429..8305376)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8303429..8305376)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bruton tyrosine kinase Neighboring gene long non-coding RNA:CR43752 Neighboring gene wollknaeuel Neighboring gene Oligosaccharide transferase gamma subunit Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 14 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of components of the dystrophin complex in Drosophila. Greener MJ, et al. FEBS Lett, 2000 Sep 29. PMID 11018515
    2. Embryonic expression patterns of the Drosophila dystrophin-associated glycoprotein complex orthologs. Dekkers LC, et al. Gene Expr Patterns, 2004 Mar. PMID 15161095
    3. The roles of the dystrophin-associated glycoprotein complex at the synapse. Pilgram GS, et al. Mol Neurobiol, 2010 Feb. PMID 19899002, Free PMC Article
    4. Differential activity of EWG transcription factor isoforms identifies a subset of differentially regulated genes important for synaptic growth regulation. Haussmann IU, et al. Dev Biol, 2010 Dec 15. PMID 20854801
    5. Systematic identification of genes regulating synaptic remodeling in the Drosophila visual system. Araki T, et al. Genes Genet Syst, 2020 Aug 27. PMID 32493879

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sarcoglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sarcoglycan complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sarcoglycan complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sarcoglycan alpha
    Names
    CG7851-PA
    CG7851-PB
    CG7851-PC
    Scgalpha-PA
    Scgalpha-PB
    Scgalpha-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8303429..8305376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078786.3 → NP_523510.1  sarcoglycan alpha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GT66, Q9VLQ0
      Related
      FBpp0079217
      Conserved Domains (1) summary
      pfam05510
      Location:4 → 409
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    2. NM_001273317.1 → NP_001260246.1  sarcoglycan alpha, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260246.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF78
      Conserved Domains (1) summary
      pfam05510
      Location:4 → 409
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    3. NM_001273316.1 → NP_001260245.1  sarcoglycan alpha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260245.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCJ9
      Conserved Domains (1) summary
      pfam05510
      Location:4 → 372
      Sarcoglycan_2; Sarcoglycan alpha/epsilon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCJ9 M9PCJ9
    M9PF78 M9PF78
    Q9GT66 Q9GT66
    Q9VLQ0 Q9VLQ0

    Gene LinkOut

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