U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Vha100-5 Vacuolar H[+] ATPase 100kD subunit 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34587, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Vha100-5provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase 100kD subunit 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0032373
    Locus tag
    Dmel_CG12602
    See related
    AllianceGenome:FB:FBgn0032373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12602; Dmel\CG12602; vha100-5
    Summary
    Predicted to enable ATPase binding activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport and vacuolar acidification. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Vha100-5 in Genome Data Viewer
    Location:
    33A1-33A1; 2-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11738948..11744524)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11738948..11744524)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44143 Neighboring gene long non-coding RNA:CR44145 Neighboring gene antisense RNA:CR44144 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing. Macdonald SJ, et al. Genetics, 2022 Mar 3. PMID 35100395, Free PMC Article
    2. Investigation of Isoform Specific Functions of the V-ATPase a Subunit During Drosophila Wing Development. Mo D, et al. Front Genet, 2020. PMID 32754202, Free PMC Article
    3. Association of Wolbachia with Gene Expression in Drosophila Testes. Dou W, et al. Microb Ecol, 2021 Oct. PMID 33555369
    4. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Overend G, et al. Sci Rep, 2016 Jun 2. PMID 27250760, Free PMC Article
    5. Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Allan AK, et al. Physiol Genomics, 2005 Jul 14. PMID 15855386

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    vacuolar H[+] ATPase 100kD subunit 5
    Names
    CG12602-PA
    CG12602-PB
    Vha100-5-PA
    Vha100-5-PB
    vacuolar H[+] ATPase subunit 100-5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11738948..11744524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273459.1 → NP_001260388.1  vacuolar H[+] ATPase 100kD subunit 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKF6
      Conserved Domains (2) summary
      COG1269
      Location:5 → 805
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 804
      V_ATPase_I; V-type ATPase 116kDa subunit family

    2. NM_135671.2 → NP_609515.1  vacuolar H[+] ATPase 100kD subunit 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKF6
      Related
      FBpp0079839
      Conserved Domains (2) summary
      COG1269
      Location:5 → 805
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 804
      V_ATPase_I; V-type ATPase 116kDa subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YU68 Q7YU68
    Q9VKF6 Q9VKF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous