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    Mal-A4 Maltase A4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mal-A4provided by FlyBase
    Official Full Name
    Maltase A4provided by FlyBase
    Primary source
    FLYBASE:FBgn0033294
    Locus tag
    Dmel_CG8693
    See related
    AllianceGenome:FB:FBgn0033294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8693; Dmel\CG8693; Drome_A4; MA4; mal_A4
    Summary
    Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mal-A4 in Genome Data Viewer
    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8458815..8460884)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4346320..4348389)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Maltase A2 Neighboring gene Maltase A3 Neighboring gene Maltase A5 Neighboring gene Maltase A6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative Transcriptomic Analysis Revealing the Potential Mechanisms of Erythritol-Caused Mortality and Oviposition Inhibition in Drosophila melanogaster. Li L, et al. Int J Mol Sci, 2024 Mar 27. PMID 38612549, Free PMC Article
    2. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425
    3. Genetic and genomic analyses of Drosophila melanogaster models of chromatin modification disorders. MacPherson RA, et al. Genetics, 2023 Aug 9. PMID 37036413, Free PMC Article
    4. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
    5. Association of Wolbachia with Gene Expression in Drosophila Testes. Dou W, et al. Microb Ecol, 2021 Oct. PMID 33555369

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maltase A4
    Names
    CG8693-PA
    Mal-A4-PA
    NP_610381.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8458815..8460884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136537.3 → NP_610381.1  maltase A4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7E8
      Related
      FBpp0087827
      Conserved Domains (2) summary
      cd11328
      Location:24 → 492
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      pfam00128
      Location:47 → 401
      Alpha-amylase; Alpha amylase, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7E8 A1Z7E8

    Gene LinkOut

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