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    Lsm10 Lsm10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lsm10provided by FlyBase
    Official Full Name
    Lsm10provided by FlyBase
    Primary source
    FLYBASE:FBgn0033554
    Locus tag
    Dmel_CG12938
    See related
    AllianceGenome:FB:FBgn0033554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12938; dLsm10; Dmel\CG12938
    Summary
    Predicted to enable U7 snRNA binding activity and histone pre-mRNA DCP binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in histone locus body. Part of cytoplasmic U snRNP body. Orthologous to human LSM10 (LSM10, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lsm10 in Genome Data Viewer
    Location:
    47C1-47C1; 2-63 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10821098..10821640, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6708603..6709145, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene diego Neighboring gene Proteasome beta5 subunit Neighboring gene Ribosomal protein S15Ab Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development. Godfrey AC, et al. RNA, 2009 Sep. PMID 19620235, Free PMC Article
    2. Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP. Rieder LE, et al. Genes Dev, 2017 Jul 15. PMID 28838946, Free PMC Article
    3. Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster. Azzouz TN, et al. RNA, 2003 Dec. PMID 14624008, Free PMC Article
    4. Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis. Tatomer DC, et al. J Cell Biol, 2016 Jun 6. PMID 27241916, Free PMC Article
    5. The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway. Lee L, et al. Dev Biol, 2009 Aug 1. PMID 19464282

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The different terminal developmental phenotypes result from the participation of Lsm10 and Lsm11 in an essential function that is distinct from histone pre-mRNA processing and that is independent of U7 snRNA.
      Title: The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development.
    2. The product of this gene has been functionally characterized as the U7 snRNP-associated Sm-like protein Lsm10
      Title: Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables U7 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone pre-mRNA DCP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cytoplasmic U snRNP body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic U snRNP body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in histone locus body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lsm10
    Names
    CG12938-PA
    Lsm10-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10821098..10821640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136771.3 → NP_610615.1  Lsm10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610615.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8C4, G2J5Y7
      Related
      FBpp0087343
      Conserved Domains (1) summary
      cd01733
      Location:7 → 84
      LSm10; Like-Sm protein 10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8C4 A1Z8C4

    Gene LinkOut

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