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    CG16935 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG16935provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033883
    Locus tag
    Dmel_CG16935
    See related
    AllianceGenome:FB:FBgn0033883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG16935; DM_7303260
    Summary
    Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Used to study childhood-onset dystonia with optic atrophy and basal ganglia abnormalities. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG16935 in Genome Data Viewer
    Location:
    50C6-50C6; 2-68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13860349..13862002, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9747854..9749507, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44367 Neighboring gene uncharacterized protein Neighboring gene tumbleweed Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-like activating enzyme 3 Neighboring gene short stop Neighboring gene DJ-1alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels. Dutta D, et al. Nat Metab, 2023 Sep. PMID 37653044, Free PMC Article
    2. TEMPLE: analysing population genetic variation at transcription factor binding sites. Litovchenko M, et al. Mol Ecol Resour, 2016 Nov. PMID 27106869
    3. Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. Axelsson E, et al. BMC Bioinformatics, 2011 Aug 17. PMID 21849035, Free PMC Article
    4. Selection, recombination and demographic history in Drosophila miranda. Bachtrog D, et al. Genetics, 2006 Dec. PMID 17028331, Free PMC Article
    5. The Stearoyl-CoA Desaturase-1 (Desat1) in Drosophila cooperated with Myc to Induce Autophagy and Growth, a Potential New Link to Tumor Survival. Paiardi C, et al. Genes (Basel), 2017 Apr 28. PMID 28452935, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of ceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG16935-PA
    CG16935-PB
    Enoyl-[acyl-carrier-protein] reductase, mitochondrial
    trans-2-enoyl-CoA reductase, mitochondrial
    NP_001286396.1
    NP_610914.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13860349..13862002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137070.2 → NP_610914.2  uncharacterized protein Dmel_CG16935, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610914.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H8F4T6, Q9V6U9
      UniProtKB/TrEMBL
      Q58CJ2
      Related
      FBpp0086748
      Conserved Domains (2) summary
      cd08290
      Location:23 → 355
      ETR; 2-enoyl thioester reductase (ETR)
      COG0604
      Location:23 → 349
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    2. NM_001299467.1 → NP_001286396.1  uncharacterized protein Dmel_CG16935, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H8F4T6, Q9V6U9
      UniProtKB/TrEMBL
      Q58CJ2
      Conserved Domains (2) summary
      cd08290
      Location:23 → 355
      ETR; 2-enoyl thioester reductase (ETR)
      COG0604
      Location:23 → 349
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H8F4T6 H8F4T6
    Q9V6U9.2 Q9V6U9

    Gene LinkOut

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