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    DJ-1alpha DJ-1alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DJ-1alphaprovided by FlyBase
    Official Full Name
    DJ-1alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033885
    Locus tag
    Dmel_CG6646
    See related
    AllianceGenome:FB:FBgn0033885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6646; dDJ-1alpha; DJ-1; DJ-1 alpha; DJ-1a; DJ-1A; dj-1alpha; Dj-1alpha; Dmel\CG6646
    Summary
    Predicted to enable peroxiredoxin activity and protein deglycase activity. Involved in several processes, including dopamine metabolic process; mitochondrial ATP synthesis coupled electron transport; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in mitochondrion. Is expressed in adult head and spermatozoon. Used to study Parkinson's disease; Parkinson's disease 7; and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DJ-1alpha in Genome Data Viewer
    Location:
    50C9-50C9; 2-68 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13942534..13943377, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9830039..9830882, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene short stop Neighboring gene Argonaute-1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L53 Neighboring gene Regulatory particle non-ATPase 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. Faust K, et al. BMC Neurosci, 2009 Sep 1. PMID 19723328, Free PMC Article
    2. Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits. Lavara-Culebras E, et al. Gene, 2007 Oct 1. PMID 17651920
    3. Analysis of two P-element enhancer-trap insertion lines that show expression in the giant fibre neuron of Drosophila melanogaster. Allen MJ, et al. Genes Brain Behav, 2007 Jun. PMID 16879616
    4. Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Menzies FM, et al. Curr Biol, 2005 Sep 6. PMID 16139214
    5. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Meulener M, et al. Curr Biol, 2005 Sep 6. PMID 16139213

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. trimethyl isocitrate (TIC), a cell permeable isocitrate, protected mammalian DJ-1 null DA cells from oxidative stress in an IDH-dependent manner. These results suggest that isocitrate and its derivatives are novel treatments for Parkinson's disease associated with DJ-1 dysfunction
      Title: Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).
    2. Flies deleted for DJ-1 manifest similar defects as pink1 and parkin mutants: male sterility, shortened lifespan, and reduced climbing ability.
      Title: DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.
    3. Overexpression of DJ-1alpha in dopaminergic neurons is sufficient to confer protection against paraquat insult.
      Title: Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress.
    4. Data show that DJ-1 is a key negative regulator of PTEN that may be a useful prognostic marker for cancer.
      Title: DJ-1, a novel regulator of the tumor suppressor PTEN.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peroxiredoxin activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein deglycase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glyoxal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial ATP synthesis coupled electron transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DJ-1alpha
    Names
    CG6646-PA
    DJ-1A
    DJ-1alpha-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13942534..13943377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137072.1 → NP_610916.1  DJ-1alpha [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9J4
      Related
      FBpp0086741, FBtr0087615
      Conserved Domains (1) summary
      cl28603
      Location:33 → 210
      ThiJ; Putative intracellular protease/amidase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9J4.1 A1Z9J4

    Gene LinkOut

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