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    cGlr1 cGAS-like receptor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36744, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cGlr1provided by FlyBase
    Official Full Name
    cGAS-like receptor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034047
    Locus tag
    Dmel_CG12970
    See related
    AllianceGenome:FB:FBgn0034047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12970; cGLR1; Dm-cGLR1; Dmel\CG12970
    Summary
    Enables 2',3'-cyclic GMP-AMP synthase activity; 3',2'-cyclic GMP-AMP synthase activity; and double-stranded RNA binding activity. Involved in cGAS/STING signaling pathway; immune response involved in response to exogenous dsRNA; and response to virus. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cGlr1 in Genome Data Viewer
    Location:
    52C8-52C8; 2-75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15855961..15857522)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11743466..11745027)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tungus Neighboring gene Pox neuro Neighboring gene uncharacterized protein Neighboring gene Glycerophosphate oxidase 1 Neighboring gene Rap1 interacting factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cGLRs are a diverse family of pattern recognition receptors in innate immunity. Li Y, et al. Cell, 2023 Jul 20. PMID 37379839, Free PMC Article
    2. The virus-induced cyclic dinucleotide 2'3'-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila. Cai H, et al. Immunity, 2023 Sep 12. PMID 37659413
    3. cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Slavik KM, et al. Nature, 2021 Sep. PMID 34261127, Free PMC Article
    4. Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage. Moehlman AT, et al. PLoS Genet, 2023 Jul. PMID 37440574, Free PMC Article
    5. cGAS-like receptor-mediated immunity: the insect perspective. Cai H, et al. Curr Opin Immunol, 2022 Feb. PMID 35149240

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two cGAS-like receptors induce antiviral immunity in Drosophila.
      Title: Two cGAS-like receptors induce antiviral immunity in Drosophila.
    2. cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
      Title: cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2',3'-cyclic GMP-AMP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',2'-cyclic GMP-AMP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGAS/STING signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cGAS/STING signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response involved in response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to exogenous dsRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cGAS-like receptor 1
    Names
    CG12970-PC
    cGlr1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15855961..15857522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176180.2 → NP_788360.2  cGAS-like receptor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788360.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZA55
      Conserved Domains (1) summary
      pfam03281
      Location:60 → 342
      Mab-21; Mab-21 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA55.2 A1ZA55

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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