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    RhoGAP54D Rho GTPase activating protein at 54D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGAP54Dprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 54Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034249
    Locus tag
    Dmel_CG6477
    See related
    AllianceGenome:FB:FBgn0034249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6477; Dmel\CG6477
    Summary
    Predicted to enable GTPase activator activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in cytoplasm. Is expressed in leg. Orthologous to human ARHGAP19 (Rho GTPase activating protein 19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP54D in Genome Data Viewer
    Location:
    54C11-54C12; 2-83 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17586425..17590884, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13473930..13478389, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45274 Neighboring gene antisense RNA:CR45275 Neighboring gene uncharacterized protein Neighboring gene icln Neighboring gene uncharacterized protein Neighboring gene SMAD specific E3 ubiquitin protein ligase Neighboring gene NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
    2. Regulating axon branch stability: the role of p190 RhoGAP in repressing a retraction signaling pathway. Billuart P, et al. Cell, 2001 Oct 19. PMID 11672527
    3. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. Greenberg L, et al. Mech Dev, 2011 Jan-Feb. PMID 20851182, Free PMC Article
    4. The nonspecific lethal complex is a transcriptional regulator in Drosophila. Raja SJ, et al. Mol Cell, 2010 Jun 25. PMID 20620954
    5. Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors. Das TK, et al. Oncogene, 2013 Jun 27. PMID 22890320, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 54D
    Names
    CG6477-PA
    CG6477-PC
    RhoGAP54D-PA
    RhoGAP54D-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17586425..17590884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137392.3 → NP_611236.2  Rho GTPase activating protein at 54D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611236.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAW3, Q058T7
      Related
      FBpp0086058
      Conserved Domains (1) summary
      cl02570
      Location:107 → 313
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. NM_001274131.2 → NP_001261060.1  Rho GTPase activating protein at 54D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAW3, Q058T7
      Conserved Domains (1) summary
      cl02570
      Location:107 → 313
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAW3 A1ZAW3
    Q8IGY7 Q8IGY7

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