List Lithium-inducible SLC6 transporter [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Listprovided by FlyBase
Official Full Name: Lithium-inducible SLC6 transporterprovided by FlyBase
Primary source: FLYBASE:FBgn0034381
Locus tag: Dmel_CG15088
See related: AllianceGenome:FB:FBgn0034381
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15088; Dmel\CG15088; DmNAT2; LIST
Summary: Predicted to enable L-amino acid transmembrane transporter activity; amino acid:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Involved in response to lithium ion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult brain; adult gut; adult head; and adult ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18727817..18730281, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14615322..14617786, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The List transporter confers resistance to lithium toxicity, possibly as a consequence of its amino acid transporter activity in CNS glia.
Title: A putative amino acid transporter of the solute carrier 6 family is upregulated by lithium and is required for resistance to lithium toxicity in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid:monoatomic cation symporter activity	ISM Inferred from Sequence Model more info	PubMed
enables amino acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid transmembrane transport	ISM Inferred from Sequence Model more info	PubMed
involved_in glycine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to lithium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain