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    Hs3st-A Heparan sulfate 3-O sulfotransferase-A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37161, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs3st-Aprovided by FlyBase
    Official Full Name
    Heparan sulfate 3-O sulfotransferase-Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053147
    Locus tag
    Dmel_CG33147
    See related
    AllianceGenome:FB:FBgn0053147
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15074; CG15075; CG15076; CG30123; CG30124; CG33147; dHS3OSTA; Dmel\CG33147; HS3ST; lincRNA.S3111
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Is expressed in several structures, including adult head; central brain primordium; ganglia; sense organ; and sensory nervous system primordium. Orthologous to several human genes including HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hs3st-A in Genome Data Viewer
    Location:
    55E9-55F1; 2-86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18718114..18754675)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14605619..14642180)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR33942 Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 51 Neighboring gene mir-4982 stem loop Neighboring gene Lithium-inducible SLC6 transporter Neighboring gene long non-coding RNA:CR30121 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12b2 Neighboring gene jabba Neighboring gene transfer RNA:Leucine-AAG 1-4 Neighboring gene Multiple C2 domain and transmembrane region protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila heparan sulfate 3-O sulfotransferase B null mutant is viable and exhibits no defects in Notch signaling. Guo Y, et al. J Genet Genomics, 2014 Jul 20. PMID 25064676
    2. A putative amino acid transporter of the solute carrier 6 family is upregulated by lithium and is required for resistance to lithium toxicity in Drosophila. Kasuya J, et al. Neuroscience, 2009 Oct 20. PMID 19619614, Free PMC Article
    3. The same domain of Su(Hw) is required for enhancer blocking and direct promoter repression. Melnikova L, et al. Sci Rep, 2019 Mar 29. PMID 30926937, Free PMC Article
    4. Hs3st-A and Hs3st-B regulate intestinal homeostasis in Drosophila adult midgut. Guo Y, et al. Cell Signal, 2014 Nov. PMID 25049075
    5. Heparan sulfate proteoglycans in Drosophila neuromuscular development. Kamimura K, et al. Biochim Biophys Acta Gen Subj, 2017 Oct. PMID 28645846

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate 3-O sulfotransferase-A
    Names
    CG33147-PA
    CG33147-PB
    Hs3st-A-PA
    Hs3st-A-PB
    NP_001286589.1
    NP_788409.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18718114..18754675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299660.1 → NP_001286589.1  heparan sulfate 3-O sulfotransferase-A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRE7, Q9V8M0
      Conserved Domains (1) summary
      cl21551
      Location:242 → 587
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_176229.3 → NP_788409.1  heparan sulfate 3-O sulfotransferase-A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRE7, Q9V8M0
      Related
      FBpp0085791
      Conserved Domains (1) summary
      cl21551
      Location:242 → 587
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRE7 Q8MRE7
    Q9V8L9 Q9V8L9

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