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    ru roughoid [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44856, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ruprovided by FlyBase
    Official Full Name
    roughoidprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003295
    Locus tag
    Dmel_CG1214
    See related
    AllianceGenome:FB:FBgn0003295
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1214; Dmel\CG1214; rho-3; Rho-3; Rho-related [62A1]; rho3; Rho3; Ru
    Summary
    Enables serine-type endopeptidase activity. Involved in several processes, including compound eye morphogenesis; epidermal growth factor receptor ligand maturation; and epithelial cell migration, open tracheal system. Located in apical part of cell; bounding membrane of organelle; and endoplasmic reticulum. Is expressed in several structures, including adult heart; embryonic head sensory system; organism subdivision; and sensory nervous system primordium. Orthologous to several human genes including RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    61F8-61F8; 3-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1370628..1387437)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1370628..1387437)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene indra Neighboring gene Protein tyrosine phosphatase 61F Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glutamic acid-CTC 3-1 Neighboring gene transfer RNA:Glutamic acid-CTC 3-2 Neighboring gene transfer RNA:Glutamic acid-CTC 3-3 Neighboring gene transfer RNA:Glutamic acid-CTC 3-4 Neighboring gene transfer RNA:Glutamic acid-CTC 3-5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induced crossing-over in the presterile broods of Drosophila melanogaster males. Hannah-Alava A. Genetica, 1968. PMID 5722790
    2. Surface structure of the compound eye of various Drosophila species and eye mutants of Drosophila melanogaster. Stumm-Tegethoff BF, et al. Theor Appl Genet, 1974 Jan. PMID 24424475
    3. Developmental roles of Rhomboid proteases. Shilo BZ. Semin Cell Dev Biol, 2016 Dec. PMID 27423914
    4. Purine-resistant Drosophila melanogaster result from mutations in the adenine phosphoribosyltransferase structural gene. Johnson DH, et al. Proc Natl Acad Sci U S A, 1983 May. PMID 6407004, Free PMC Article
    5. Formal relations between Om mutants and their suppressors in Drosophila ananassae. Hinton CW. Genetics, 1988 Dec. PMID 2852141, Free PMC Article

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrate that rhomboid 3 mediated activation of the EGF receptor pathway is necessary for proper adult cardiac function
      Title: Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila.
    2. Rho-3, which is expressed in the developing eye, cleaves the Spitz precursor and Star already in the endoplasmic reticulum, in addition to its activity in the late compartment.
      Title: Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases.
    3. evidence presented that Rhomboid 3/EGF signalling, which originates from the midline of the Drosophila ventral nerve cord, repels tracheal ganglionic branches and prevents them from crossing it
      Title: Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye cone cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye photoreceptor fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor ligand maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor ligand maturation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor ligand maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leg disc proximal/distal pattern formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    roughoid
    Names
    CG1214-PA
    Rhomboid-3
    rhomboid
    rhomboid 3
    rhomboid3
    roughoid/rhomboid-3
    ru-PA
    NP_524790.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1370628..1387437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080051.3 → NP_524790.1  roughoid [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BML3, Q9W0F8
      Related
      FBpp0072574
      Conserved Domains (1) summary
      pfam01694
      Location:129 → 282
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0F8 Q9W0F8

    Gene LinkOut

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