Iml1 Increased minichromosome loss 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Iml1provided by FlyBase
Official Full Name: Increased minichromosome loss 1provided by FlyBase
Primary source: FLYBASE:FBgn0035227
Locus tag: Dmel_CG12090
See related: AllianceGenome:FB:FBgn0035227
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12090; Dmel\CG12090; GATOR1; iml; iml1; IMl1; SEA1
Summary: Predicted to enable GTPase activator activity. Involved in several processes, including germarium-derived cystoblast division; germline cell cycle switching, mitotic to meiotic cell cycle; and negative regulation of TORC1 signaling. Located in lysosome. Part of Seh1-associated complex. Is expressed in adult head. Used to study familial focal epilepsy with variable foci 3. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and familial focal epilepsy with variable foci 1. Orthologous to human DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 62A3-62A3; 3-0.5 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1523414..1534034, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1523414..1534034, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived cystoblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germline cell cycle switching, mitotic to meiotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germline cell cycle switching, mitotic to meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GATOR1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GATOR1 complex	TAS Traceable Author Statement more info	PubMed
part_of Seh1-associated complex	IDA Inferred from Direct Assay more info	PubMed
part_of Seh1-associated complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: increased minichromosome loss 1

Names: CG12090-PA; CG12090-PB; CG12090-PC; CG12090-PD; CG12090-PE; Iml1-PA; Iml1-PB; Iml1-PC; Iml1-PD; Iml1-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1523414..1534034 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_139361.2 → NP_647618.1 increased minichromosome loss 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647618.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRG9

Related

FBpp0072588

Conserved Domains (2) summary

cd04449
Location:1049 → 1129

DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.

pfam12257
Location:106 → 386

DUF3608; Protein of unknown function (DUF3608)
NM_167888.2 → NP_728620.1 increased minichromosome loss 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728620.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRG8

Related

FBpp0072589

Conserved Domains (2) summary

cd04449
Location:1050 → 1130

DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.

pfam12257
Location:106 → 386

DUF3608; Protein of unknown function (DUF3608)
NM_001274331.1 → NP_001261260.1 increased minichromosome loss 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261260.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDV3

Conserved Domains (2) summary

cd04449
Location:1081 → 1161

DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.

pfam12257
Location:106 → 386

DUF3608; Protein of unknown function (DUF3608)
NM_001274330.1 → NP_001261259.1 increased minichromosome loss 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261259.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PE64

Conserved Domains (2) summary

cd04449
Location:1089 → 1169

DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.

pfam12257
Location:106 → 386

DUF3608; Protein of unknown function (DUF3608)
NM_167889.2 → NP_728621.1 increased minichromosome loss 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728621.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E8NH72, Q8IRG9, Q8SY36, Q9W0E3

Related

FBpp0072587

Conserved Domains (2) summary

cd04449
Location:1122 → 1202

DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.

pfam12257
Location:100 → 385

IML1; Vacuolar membrane-associated protein Iml1