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    Cep135 Centrosomal protein 135kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39647, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep135provided by FlyBase
    Official Full Name
    Centrosomal protein 135kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036480
    Locus tag
    Dmel_CG17081
    See related
    AllianceGenome:FB:FBgn0036480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bld-10; bld10; Bld10; BLD10; Bld10p; CEP135; Cep135/bld10; CG17081; dbld10; DBld10; DCep135; DCep135/Bld10; DmBLD10; Dmel\CG17081
    Summary
    Enables microtubule binding activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of microtubule depolymerization; and non-motile cilium assembly. Located in ciliary transition zone and microtubule organizing center. Is expressed in embryonic brain; larval ventral nerve cord; organism; and spermatozoon. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8 and spermatogenic failure 26. Orthologous to several human genes including CEP135 (centrosomal protein 135). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cep135 in Genome Data Viewer
    Location:
    71B5-71B5; 3-42 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15116737..15128029)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15109837..15121129)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene CTP synthase Neighboring gene antisense RNA:CR43971 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU5-U42 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45396 Neighboring gene Protein disulfide isomerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair. Carvalho-Santos Z, et al. Dev Cell, 2012 Aug 14. PMID 22898782
    2. Conserved molecular interactions in centriole-to-centrosome conversion. Fu J, et al. Nat Cell Biol, 2016 Jan. PMID 26595382, Free PMC Article
    3. Drosophila Ana1 is required for centrosome assembly and centriole elongation. Saurya S, et al. J Cell Sci, 2016 Jul 1. PMID 27206860, Free PMC Article
    4. Comprehensive review on the molecular genetics of autosomal recessive primary microcephaly (MCPH). Naveed M, et al. Genet Res (Camb), 2018 Aug 8. PMID 30086807, Free PMC Article
    5. Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation. Roque H, et al. J Cell Sci, 2012 Dec 1. PMID 22976301

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ana1 mutants lack detectable centrosomes in vivo, that Ana1 is irreversibly incorporated into centrioles during their assembly and appears to play a more important role in maintaining Asl at centrioles than in initially recruiting Asl to centrioles...the N-terminal region of Ana1 (amino acids 1-935) is required to target Ana1 to centrioles through a direct interaction with Cep135, whereas the C-terminal region of Ana1.
      Title: Drosophila Ana1 is required for centrosome assembly and centriole elongation.
    2. The centriolar protein Bld10/Cep135 is required to establish centrosome asymmetry in Drosophila neuroblasts.
      Title: The centriolar protein Bld10/Cep135 is required to establish centrosome asymmetry in Drosophila neuroblasts.
    3. Cep135/Bld10 is not essential for cartwheel assembly or for establishing the ninefold symmetry of centrioles; rather, it appears to stabilize the connection between inner and outer centriole components.
      Title: Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation.
    4. work describes a genetically tractable system to study motile cilia formation and provides an explanation for BLD10/CEP135's role in assembling highly stable microtubule-based structures
      Title: BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair.
    5. Drosophila Bld10 is required for centriole and axoneme assembly to confer cilium motility.
      Title: Drosophila bld10 is a centriolar protein that regulates centriole, basal body, and motile cilium assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein 135kDa
    Names
    CG17081-PA
    CG17081-PB
    CG17081-PC
    Cep135-PA
    Cep135-PB
    Cep135-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15116737..15128029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202179.2 → NP_001189108.1  centrosomal protein 135kDa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSL4
      Conserved Domains (2) summary
      COG1196
      Location:203 → 963
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19219
      Location:302 → 421
      DUF342; Protein of unknown function (DUF342)

    2. NM_001274940.1 → NP_001261869.1  centrosomal protein 135kDa, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCK8
      Conserved Domains (2) summary
      COG1196
      Location:203 → 945
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19219
      Location:302 → 421
      DUF342; Protein of unknown function (DUF342)

    3. NM_140492.4 → NP_648749.3  centrosomal protein 135kDa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648749.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960T6, Q9VUL3
      Related
      FBpp0075391
      Conserved Domains (2) summary
      COG1196
      Location:203 → 957
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19219
      Location:302 → 421
      DUF342; Protein of unknown function (DUF342)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSL4 M9MSL4
    M9PCK8 M9PCK8
    Q960T6 Q960T6

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