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    CG34357 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG34357provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085386
    Locus tag
    Dmel_CG34357
    See related
    AllianceGenome:FB:FBgn0085386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12584; CG12585; CG14652; cg34357; CG41467; CG9783; Dmel\CG34357; GYC
    Old locus tag
    CG12585; CG14652; CG41467; CG9783; Dmel_CG12585; Dmel_CG14652; Dmel_CG41467; Dmel_CG9783
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to several human genes including GUCY2F (guanylate cyclase 2F, retinal). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG34357 in Genome Data Viewer
    Location:
    82B4-82C2; 3-47.1 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4491943..4558067, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (317665..383789, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene sterile affecting ciliogenesis Neighboring gene Factor interacting with poly(A) polymerase 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR31526 Neighboring gene Mucin related 82C Neighboring gene long non-coding RNA:CR45558 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. Biswas KH, et al. J Mol Evol, 2009 Jun. PMID 19495554
    2. IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia. Werner S, et al. Life Sci Alliance, 2024 May. PMID 38373798, Free PMC Article
    3. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Miozzo F, et al. Nat Commun, 2022 Mar 17. PMID 35301315, Free PMC Article
    4. Evolutionary Dynamics of Abundant Stop Codon Readthrough. Jungreis I, et al. Mol Biol Evol, 2016 Dec. PMID 27604222, Free PMC Article
    5. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c4501572-4497904 mobile_element_type = transposon:Fw2{}4362
    • Loc: c4501896-4501783 mobile_element_type = transposon:INE-1{}3829
    • Loc: c4504433-4504139 mobile_element_type = transposon:INE-1{}3831
    • Loc: c4507781-4506702 mobile_element_type = transposon:jockey2{}1193
    • Loc: c4516736-4515245 mobile_element_type = transposon:HB{}1194
    • Loc: c4518848-4518538 mobile_element_type = transposon:S{}1196
    • Loc: c4525779-4525091 mobile_element_type = transposon:Bari2{}4359
    • Loc: c4540133-4538934 mobile_element_type = transposon:1360{}1198
    • Loc: c4548312-4548087 mobile_element_type = transposon:INE-1{}3864
    • Loc: c4553265-4553105 mobile_element_type = transposon:INE-1{}3866
    • Loc: c4556140-4555709 mobile_element_type = transposon:INE-1{}4383

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG34357-PB
    CG34357-PC
    CG34357-PD
    CG34357-PE
    NP_001097681.2
    NP_001097682.1
    NP_001189166.1
    NP_001356914.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4491943..4558067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104211.2 → NP_001097681.2  uncharacterized protein Dmel_CG34357, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097681.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQT1
      Conserved Domains (5) summary
      smart00044
      Location:1074 → 1266
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:1101 → 1286
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:1052 → 1095
      HNOBA; Heme NO binding associated
      pfam07714
      Location:777 → 1035
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:763 → 1041
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001370010.1 → NP_001356914.1  uncharacterized protein Dmel_CG34357, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K026
      Conserved Domains (2) summary
      smart00044
      Location:1074 → 1266
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cl21453
      Location:763 → 1041
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001202237.2 → NP_001189166.1  uncharacterized protein Dmel_CG34357, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189166.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQT1
      Conserved Domains (5) summary
      smart00044
      Location:1074 → 1266
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:1101 → 1286
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:1052 → 1095
      HNOBA; Heme NO binding associated
      pfam07714
      Location:777 → 1035
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:763 → 1041
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001104212.2 → NP_001097682.1  uncharacterized protein Dmel_CG34357, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGY5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K026 A0A4D6K026
    A8JQT1 A8JQT1
    Q0IGY5 Q0IGY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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