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    Adk1 Adenosine kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adk1provided by FlyBase
    Official Full Name
    Adenosine kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037995
    Locus tag
    Dmel_CG3809
    See related
    AllianceGenome:FB:FBgn0037995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.193; CG3809; DmAdk1; Dmel\CG3809
    Summary
    Predicted to enable adenosine kinase activity. Predicted to be involved in AMP biosynthetic process and purine nucleobase metabolic process. Predicted to be active in cytosol and nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adk1 in Genome Data Viewer
    Location:
    87B2-87B2; 3-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12197941..12199473)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8023663..8025195)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit d2 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Threonine-TGT 1-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential response of Drosophila cell lines to extracellular adenosine. Fleischmannova J, et al. Insect Biochem Mol Biol, 2012 May. PMID 22266077
    2. An anti-inflammatory transcriptional cascade conserved from flies to humans. Pavlidaki A, et al. Cell Rep, 2022 Oct 18. PMID 36261018
    3. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
    4. Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila. McLaughlin CN, et al. Elife, 2021 Feb 8. PMID 33555999, Free PMC Article
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in purine nucleobase metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosine kinase 1
    Names
    Adk1-PA
    CG3809-PA
    NP_731676.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12197941..12199473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169457.2 → NP_731676.2  adenosine kinase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731676.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3U8, Q9VGC6
      Related
      FBpp0082018
      Conserved Domains (2) summary
      cd01168
      Location:54 → 382
      adenosine_kinase; Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine ...
      PTZ00247
      Location:50 → 392
      PTZ00247; adenosine kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T3U8 Q8T3U8

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