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    GstD8 Glutathione S transferase D8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48341, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GstD8provided by FlyBase
    Official Full Name
    Glutathione S transferase D8provided by FlyBase
    Primary source
    FLYBASE:FBgn0010044
    Locus tag
    Dmel_CG4421
    See related
    AllianceGenome:FB:FBgn0010044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4421; Dmel\CG4421; DmGST27; DmGSTD8; gst; Gst; GST; GST D27; gstD27; GstD27; gstd8; gstD8; GSTD8
    Summary
    Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including amnioserosa anlage; amnioserosa primordium; embryonic antennal sense organ; fat body/gonad primordium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See GstD8 in Genome Data Viewer
    Location:
    87B8-87B8; 3-52 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12380008..12380815)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8205730..8206537)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase D6 Neighboring gene Glutathione S transferase D7 Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase D11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila glutathione S-transferase D27: functional analysis of two consecutive tyrosines near the N-terminus. Lee HC, et al. Biochem Biophys Res Commun, 1995 Apr 6. PMID 7726854
    2. Drosophila glutathione S-transferases have sequence homology to the stringent starvation protein of Escherichia coli. Toung YP, et al. Biochem Biophys Res Commun, 1992 Jan 15. PMID 1731792
    3. Catalytic function of Drosophila melanogaster glutathione S-transferase DmGSTS1-1 (GST-2) in conjugation of lipid peroxidation end products. Singh SP, et al. Eur J Biochem, 2001 May. PMID 11358508
    4. Early-life exposure to tobacco smoke alters airway signaling pathways and later mortality in D. melanogaster. Sirocko KT, et al. Environ Pollut, 2022 Sep 15. PMID 35780997
    5. The route of infection determines Wolbachia antibacterial protection in Drosophila. Gupta V, et al. Proc Biol Sci, 2017 Jun 14. PMID 28592678, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase D8
    Names
    CG4421-PA
    Glutathione-S-transferase
    GstD8-PA
    glutathione S transferase D27
    NP_524916.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12380008..12380815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080177.4 → NP_524916.1  glutathione S transferase D8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524916.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TX89, Q9TXB7, Q9VG92
      Related
      FBpp0082047
      Conserved Domains (3) summary
      cd03177
      Location:88 → 204
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:1 → 188
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:1 → 74
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG92 Q9VG92

    Gene LinkOut

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