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    Uros2 Uroporphyrinogen III synthase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uros2provided by FlyBase
    Official Full Name
    Uroporphyrinogen III synthase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038361
    Locus tag
    Dmel_CG9589
    See related
    AllianceGenome:FB:FBgn0038361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT11468; CG9589; Dmel\CG9589
    Summary
    Predicted to enable uroporphyrinogen-III synthase activity. Predicted to be involved in uroporphyrinogen III biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Uros2 in Genome Data Viewer
    Location:
    89A5-89A5; 3-58 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15788521..15789494)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11614243..11615216)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene crossover suppressor on 3 of Gowen Neighboring gene Acylphosphatase 2 Neighboring gene non-specific lethal 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. c(3)G encodes a Drosophila synaptonemal complex protein. Page SL, et al. Genes Dev, 2001 Dec 1. PMID 11731477, Free PMC Article
    2. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article
    3. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    4. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    5. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables uroporphyrinogen-III synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uroporphyrinogen-III synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tetrapyrrole biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uroporphyrinogen III biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uroporphyrinogen III biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uroporphyrinogen III synthase 2
    Names
    CG9589-PA
    Uros2-PA
    NP_650489.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15788521..15789494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142232.2 → NP_650489.1  uroporphyrinogen III synthase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF38
      Related
      FBpp0082627
      Conserved Domains (1) summary
      cd06578
      Location:9 → 251
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZD2 Q8MZD2
    Q9VF38 Q9VF38

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