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    Nep7 Neprilysin 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43356, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nep7provided by FlyBase
    Official Full Name
    Neprilysin 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0039564
    Locus tag
    Dmel_CG5527
    See related
    AllianceGenome:FB:FBgn0039564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5527; Dmel\CG5527
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nep7 in Genome Data Viewer
    Location:
    98B6-98B6; 3-94 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27954917..27957326)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23780639..23783048)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitoferrin Neighboring gene Glycoprotein 93 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The circular RNA circATP8B(2) regulates ROS production and antiviral immunity in Drosophila. Liang W, et al. Cell Rep, 2024 Apr 23. PMID 38507406, Free PMC Article
    2. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    3. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    4. Interactions between the microbiome and mating influence the female's transcriptional profile in Drosophila melanogaster. Delbare SYN, et al. Sci Rep, 2020 Oct 23. PMID 33097776, Free PMC Article
    5. Drosophila sperm proteome evolution: Insights from comparative genomic approaches. Rettie EC, et al. Spermatogenesis, 2012 Jul 1. PMID 23087838, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neprilysin 7
    Names
    CG5527-PA
    Nep7-PA
    NP_651603.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27954917..27957326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143346.3 → NP_651603.1  neprilysin 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651603.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V584, Q9VAY0
      Related
      FBpp0084624
      Conserved Domains (2) summary
      cd08662
      Location:66 → 715
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:60 → 717
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAY0 Q9VAY0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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