Sox100B Sox100B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sox100Bprovided by FlyBase
Official Full Name: Sox100Bprovided by FlyBase
Primary source: FLYBASE:FBgn0024288
Locus tag: Dmel_CG15552
See related: AllianceGenome:FB:FBgn0024288
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12098; CG15552; CG18674; CT6009; Dmel\CG15552; dSox9; Sox100; SOX100B; Sox9; SoxB; SOXE
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in male gonad development. Predicted to be active in nucleus. Is expressed in several structures, including Malpighian tubule primordium; anal pad primordium; embryonic anal pad; gonad; and somatic cell of ovariole. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome (multiple); campomelic dysplasia; and lung cancer (multiple). Orthologous to several human genes including SOX10 (SRY-box transcription factor 10) and SOX9 (SRY-box transcription factor 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31065253..31083407)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26890975..26909129)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Sox100B Regulates Progenitor-Specific Gene Expression and Cell Differentiation in the Adult Drosophila Intestine.
Title: Sox100B Regulates Progenitor-Specific Gene Expression and Cell Differentiation in the Adult Drosophila Intestine.
Both overexpression studies in the chicken and gene replacement in the mouse clearly demonstrate that Sox100B integrates well into the gene-regulatory networks that drive early neural crest development.
Title: Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression.
Sox100B is required for somatic testis differentiation.
Title: Sox100B, a Drosophila group E Sox-domain gene, is required for somatic testis differentiation.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain